The following information is preliminary and subject to change. The full annual meeting schedule (including session dates, times, and locations) will be available in early October.
ASH provides the opportunity to browse the annual meeting program by disease. Select a disease from the dropdown list below to view all sessions within that category.
Bleeding and Clotting
ѻý Program
Anticoagulation SOS: Navigating Monitoring Conundrums
Anticoagulation monitoring challenges are encountered commonly in clinical practice. This educational session will present clinically oriented approaches to understanding and managing anticoagulation monitoring challenges associated with direct oral anticoagulant (DOAC) use, heparin monitoring, and anticoagulation for antiphospholipid antibody syndrome.
Dr. Deborah Siegal will review the potential benefits and limitations of DOAC measurement. Clinical situations in which DOAC measurement may be helpful will be discussed and DOAC testing options will be presented based on the goal of measurement.
Dr. Cheryl Maier will review the definition of heparin resistance which varies depending on specific measurements of anticoagulation and the type of assay used. Multiple causes of heparin resistance will be covered using a case-based approach to help providers troubleshoot heparin resistance and develop alternative management strategies when heparin resistance is encountered.
Prof. Hannah Cohen will summarise the use of warfarin in patients with thrombotic antiphospholipid syndrome (APS). Using a case-based approach, she will highlight key considerations in the choice of oral anticoagulant, issues that may impact on accurate monitoring of warfarin anticoagulation in APS patients, and strategies to overcome these. She will also discuss the use and monitoring of low-molecular-weight/unfractionated heparin in APS patients in particular situations.
Chair:
DeborahSiegal,MD, MSc
University of Ottawa
Ottawa,
ON,Canada
Speakers:
DeborahSiegal,MD, MSc
University of Ottawa
Ottawa,
ON,Canada
Measuring the effect of DOACs: Why, When, and How?
Cheryl LMaier,MD, PhD
Emory University
Atlanta,
GA
Troubleshooting Heparin Resistance
HannahCohen,MD, FRCP, FRCPath
University College London Hospitals NHS Foundation Trust
London,
United Kingdom
Warfarin and Heparin Monitoring in Antiphospholipid Syndrome
Beyond TTP: “Atypical” TMAs for the Hematologist
The ѻý educational session will delve into the complexities of thrombotic microangiopathies (TMAs) outside the typical presentation of thrombotic thrombocytopenic purpura (TTP).
The session will address three related disease states: Transplant-Associated Thrombotic Microangiopathy (TA-TMA), atypical Hemolytic Uremic Syndrome (aHUS) and Catastrophic Antiphospholipid Antibody Syndrome (CAPs).
The segment on TA-TMA will cover its incidence in the post-transplant period, the challenges of distinguishing TA-TMA from other post-transplant complications, and the data on emerging treatment approaches. The session will also include a comprehensive review of aHUS, focusing on its genetic underpinnings, atypical presentations, and the latest advancements in targeted therapies, such as complement inhibitors. The discussion will encapsulate the nuances of managing these atypical TMAs, highlighting case studies and clinical trials that underscore the critical role of personalized medicine in improving patient outcomes. This session will also explore Catastrophic Antiphospholipid Syndrome (CAPS), a rare and severe subtype of antiphospholipid syndrome characterized by widespread microvascular thrombi, leading to multiple organ failure. The talk will provide an overview of the pathophysiology, diagnostic criteria, and emerging treatment strategies. Discussion will also focus on distinguishing CAPS from other TMAs through clinical presentation and laboratory findings, emphasizing the importance of timely and accurate diagnosis to mitigate the high mortality rate associated with this condition.
Chair:
MarkCrowther,MS MSc LLM FRCPC FRSC
McMaster University
Hamilton,
ON,Canada
Speakers:
ԳᲹ
Washington University in St. Louis
St. Louis,
MO
Atypical HUS: Diagnosis, Management, and Discontinuation Therapy
AngLi,MD, MS
Baylor College of Medicine
Houston,
TX
Transplant Associated TMA: The Conundrum of Diagnosis and Treatment
MarkCrowther,MS MSc LLM FRCPC FRSC
McMaster University
Hamilton,
ON,Canada
Catastrophic Antiphospholipid Syndrome (CAPS) and Anticoagulant-Refractory APS
Challenges in Cancer-Associated Thrombosis
Patients with cancer have an increased risk of venous thromboembolism (VTE) for which anticoagulation is the treatment of choice. However, they also commonly face complications related to cancer itself or cancer therapies that create unique challenges for the management of cancer-associated thrombosis. This educational session will explore the evidence for best practices in assessing and managing challenging scenarios in patients with cancer-associated thrombosis, including patients with brain metastasis, recurrent venous thromboembolism despite anticoagulation, and thrombocytopenia.
Dr. Leader will summarize the evidence of anticoagulant use in patients with brain metastasis, discuss risks and benefits of anticoagulation in these patients and optimal management strategies in this high-risk population.
Dr. Zwicker will discuss the challenges of evaluating and managing patients with cancer and new or progressive VTE on anticoagulation. He will discuss diagnostic strategies to identify etiologies for anticoagulant failure and provide therapeutic options in this patient population.
Dr. Ay will address the challenge of concurrent VTE and thrombocytopenia in patients with cancer. He will summarize data from available literature, review guidance recommendations, and discuss management strategies and future directions in these patients.
Chair:
ճ-²Բ,Ѷ,ѱʱ
Ottawa Hospital Research Institute, University of Ottawa
Ottawa,
ON,Canada
Speakers:
,Ѷ
Memorial Sloan Kettering Cancer Center
New York,
NY
Management of Anticoagulation in Patients With Brain Metastasis
ڴڰܷɾ,Ѷ
Memorial Sloan Kettering
NYC,
NY
Trousseau’s Syndrome: Management of Refractory VTE
侱
Medical University of Vienna
Vienna,
Austria
Treatment of VTE in the Thrombocytopenic Cancer Patient
Hematologic Challenges at the End-of-Life
Management of hematologic conditions for patients at the end of life is both a challenge and an opportunity to provide evidence-based, compassionate care. Care of seriously ill patients entails specific considerations—including incorporating life expectancy, addressing symptom burden, and navigating hospice—that apply across the spectrum of hematologic diseases. Further, there is a growing, multidisciplinary evidence base to support treatment decision-making that this session will review. First, we will discuss optimization of end-of-life care in transfusion-dependent hematologic malignancies. We will then focus on a strategy for management of anticoagulant medications in those with limited life expectancy. Finally, we will address prognostication and palliative care in sickle cell disease.
Dr. Loh will highlight challenges and barriers in implementing timely end-of-life-care and potential strategies to overcome these barriers for patients with transfusion-dependent hematologic malignancies.
Dr. Park's talk "Anticoagulation at the End of Life: Whether, When, and How to Treat," will focus on state-of-the-art evidence from hematology and palliative care science to inform management of anticoagulant medications in patients with life-limiting illness. Dr. Parks will discuss the complexities of anticoagulation at the end of life, opportunities to enhance our knowledge, and outline an approach to care that is based on patients’ values.
Dr. Johnston will discuss challenges in providing high quality end-of-life care for people with SCD, including disease-related, communication-related, and systemic-related challenges and discuss strategies to overcome these challenges, including use of primary and specialty palliative care.
Chair:
Anna L.Parks,MD
University of Utah Health
Salt Lake City,
UT
Speakers:
Kah Poh (Melissa)Loh,MD
University of Rochester
Rochester,
NY
Challenges in Hospice and End-of-Life Care in the Transfusion-Dependent Patient
Anna L.Parks,MD
University of Utah Health
Salt Lake City,
UT
Anticoagulation at the End of Life: Whether, When, and How to Treat
Emily EJohnston
University of Alabama At Birmingham
Birmingham,
AL
End-of-Life in the Sickle Cell Patient: Life Expectancy and the Role of Palliative Care
Hematologic Management of the Patient with Heavy Menstrual Bleeding
Heavy menstrual bleeding (HBM) has an important impact on the physical, emotional and social well-being, and in adolescents, can be the only clinical sign of an underlying bleeding disorder. Due to several medical, economic and social factors, it remains a significantly underdiagnosed and undertreated condition. Hematologists play an important role in the evaluation and care of patients with anemia from chronic blood loss, and may be the first clinicians to identify HMB as its cause. This education session will describe a clinical multidisciplinary approach to the evaluation and treatment of patients presenting with HMB, with a special focus on adolescents. It will provide an overview of diagnostic and management strategies to broaden the tools available to hematologists caring for these patients in different clinical settings.
Dr. Allison P Wheeler will discuss the various tools available for the quantification of menstrual blood loss, including those that evaluate the effect of HMB on quality of life; followed by a description of non-surgical (hormonal and non-hormonal) treatments of HMB, their efficacy, contraindications and selection of the most appropriate therapy using shared decision-making.
Dr. Juliana Perez Botero will present a focused approach to laboratory testing (screening and confirmatory) for patients presenting with HMB in whom von Willebrand Disease is suspected, with emphasis on the effect of pre-analytical variables and testing methodology on the results and their clinical interpretation.
Dr. Janice Staber will discuss the value of multidisciplinary clinics specializing in the care of adolescents with HMB, including their critical components and different care delivery models, and share important lessons learned during the development and implementation of one of these clinics.
Chair:
JulianaPerez Botero,MD
Versiti
Milwaukee,
WI
Speakers:
Allison PWheeler,MD/MSCI
Washington Center for Bleeding Disorders
Seattle,
WA
Quantifying Menorrhagia and Overview of Non-Surgical Management of Heavy Menstrual Bleeding
JulianaPerez Botero,MD
Versiti
Milwaukee,
WI
Von Willebrand Disease and Heavy Menstrual Bleeding: When and How to Test
Ծٲ,Ѷ
University of Iowa Stead Family Children's Hospital
Iowa City,
IA
Heavy Menstrual Bleeding Clinics for Adolescents
HIT-and-Run: Challenges in Diagnosis and Management of Heparin-Induced Thrombocytopenia
In hospitalized patients, the diagnosis and management of heparin induced thrombocytopenia (HIT) is a recurrent challenge. To this end, this session will 1) provide evidence-based practical guidance in the diagnosis and management of suspected and confirmed HIT; 2) classify anti-platelet factor 4 (PF4) antibody mediated disorders (autoimmune HIT), their relationship to heparin exposure, and the role of rapid PF4 and platelet activation assays in diagnosis; and 3) review alternative management strategies when heparin cessation and non-heparin anticoagulants are insufficient in patients who have refractory HIT, experience acute bleeding, or are planned to undergo cardiac surgery. Emphasizing evidence-based strategies, this session will provide practical approaches and system-level interventions for high-quality care.
Chair:
մDzDzԷɳܱԱ,Ѷ,ѳ
Duke University
Durham,
NC
Speakers:
Jori E.May,MD
University of Alabama at Birmingham
Birmingham,
AL
Practical Guide to Diagnosis and Management of “Typical” HIT(T)
մDzDzԷɳܱԱ,Ѷ,ѳ
Duke University
Durham,
NC
Alternative Approaches to Management of HIT in Complex Scenarios, including Cardiac Surgery
Ѳܱ,Ѷ
University College London
London,
ENG,United Kingdom
Demystifying Autoimmune HIT: What It Is, When to Test, and How to Treat
Sex Hormones, Contraceptives, and Thrombotic Risk: Where Are We Now?
Venous thromboembolism is a common disease, with an incidence of one to three per 1000 individuals per year. Numerous risk factors are known, which can be divided into genetic and acquired. One of the most well-known acquired risk factors is exposure to endogenous (i.e. pregnancy) and exogenous female hormones, including oral contraceptive use, hormone substitution therapy, and gender-affirming hormone therapy. Thrombosis specialists are frequently consulted about optimal hormonal therapy in individuals with an increased risk of venous thromboembolism, as well as optimal management of pregnancy-related venous thromboembolism.
Dr Leslie Skeith will cover contraceptive-related VTE risk by agent and by clinical scenario, including in patients with inherited thrombophilia, systemic lupus erythematosus with or without antiphospholipid antibodies or antiphospholipid syndrome, and sickle cell disease considering contraception. Relevant clinical practice guidelines are reviewed. A multidisciplinary approach to counselling is needed for patient-focused decision-making.
Dr Joseph Shatzel will explore the hematologic complications of gender-affirming therapy, with a particular focus on managing and mitigating the thrombotic risks linked to exogenous estrogen use. He will detail existing data on thrombotic risks reported in transgender individuals and provide insights from studies involving cisgender women and men who receive exogenous estrogen and testosterone, providing important contextual background. He will delve into strategies for addressing testosterone-induced erythrocytosis and iron deficiency in transgender individuals undergoing hormone therapy.
Dr Saskia Middeldorp will present clinical cases of VTE related to hormonal contraceptive use and pregnancy to illustrate key considerations for clinical practice. Practice points for primary VTE treatment and the evidence on the risk of recurrent VTE and bleeding in this population are detailed. The potential value of thrombophilia testing is described including the: “who, why, when, what and how”. We also discuss key aspects of shared decision making for anticoagulant duration, including a reduced dose anticoagulant strategy in hormone-related VTE.
Chair:
SaskiaMiddeldorp,MD, PhD
Radboud university medical center
Nijmegen,
Netherlands
Speakers:
ٳ
University of Calgary
Calgary,
AB,Canada
Estrogen, Progestin, and Beyond: Thrombotic Risk and Contraceptive Choices
Joseph J.Shatzel,MD
Oregon Health and Science University
Portland,
OR
Gender-Affirming Hormone Therapy in the Transgender Patient: Influence on Thrombotic Risk
SaskiaMiddeldorp,MD, PhD
Radboud university medical center
Nijmegen,
Netherlands
Hormone-Related Thrombosis: Duration of Anticoagulation, Risk of Recurrence, and the Role of Hypercoagulability Testing
The Expanding Landscape of Treatment for ITP
The management of Immune Thrombocytopenia (ITP) has seen a renaissance in the available therapies and in the approach to patients with the diagnosis in recent years. This has lead to an expanding number of therapeutic options for patients and physicians to consider as they embark on their therapeutic journey with ITP. Dr. Waleed Ghanima will discuss the new approaches incorporating combination strategies in management of patients with ITP including suggestions for when to consider moving beyond mono therapy for ITP. Dr. Annemarie Fogerty will then discuss updates on ITP in pregnancy, a special category of ITP with implications for both maternal and fetal health and provide the most information on both treatments and outcomes. Finally, Dr. Michele Lambert will then describe current clinical trials (or recently completed) and provide information on novel therapeutics that are in development as well as the current treatment gaps where additional study is needed.
Chair:
Michele P.Lambert,MD
Children's Hospital of Philadelphia
Philadelphia,
PA
Speakers:
²ҳԾ,Ѷ,ʳ
Østfold Hospital
Gralum,
Norway
Insights on Treatment of ITP: Algorithm for Management and Role of Multi-Modal Therapy
Annemarie EFogerty,M.D.
Massachusetts General Hospital
Boston,
MA
Management of ITP during Pregnancy
Michele P.Lambert,MD
Children's Hospital of Philadelphia
Philadelphia,
PA
On the Horizon: Upcoming New Agents for the Management of ITP
Vascular Anomalies, Vascular Malformations, and the Role of the Hematologist
Vascular anomalies have traditionally been managed by surgical and interventional radiology colleagues. However, an evolving understanding of the pathophysiology, genetic landscape and hematologic outcomes will necessitate involvement from hematologists and oncologists for comprehensive care. This session will explore the molecular underpinnings and genetic factors of these conditions, highlighting the shift towards targeted medical therapies informed by recent discoveries in crucial signaling pathways. The talks will also cover the management of hemostasis and thrombosis risks, stressing the need for a multidisciplinary approach to diagnostics and treatment to enhance patient safety and outcomes. Together, these talks will shed light on the latest scientific advancements and their translation into clinical practices highlighting the pivotal role hematologists and oncologists play in this specialized care.
Dr. Vikkula will present an overview of the current understanding of the pathophysiological foundations of vascular anomalies. He will examine how genetic associations across various clinical cases inform the diagnostic work-up and classification of these conditions. Additionally, he will discuss the pathophysiological effects of the characterized pathogenic variants, which underlie the basis of developing targeted medical therapies for vascular anomalies.
Dr. Borst’s talk will review currently available medical therapies for vascular anomalies, review guidelines for drug dosing and monitoring, and introduce some novel therapeutics. The discovery of somatic pathogenic variants in thePI3K/AKT/mTOR and Ras/MAPKintracellular signaling pathways as drivers of vascular anomalies has led to a new era of precision medicine for these malformations and tumors. Hematologists/oncologists are critical to the care of patients with vascular anomalies, owing to expertise in managing targeted medical therapies.
Dr. Crary’s talk will focus on the evolving role of hematologists in diagnosing and managing consumptive coagulopathy associated with vascular anomalies such as kaposiform hemangioendothelioma and slow-flow vascular malformations She will emphasize the importance of interdisciplinary approaches, especially in peri-operative settings, to prevent complications like bleeding and venous thromboembolism. The talk illustrates the use of clinical signs, imaging, laboratory findings, and anticoagulation therapy to improve patient outcomes.
Chair:
Shelley ECrary,MD, MS
Arkansas Children's Hospital
Little Rock,
AR
Speakers:
MiikkaVikkula,MD, PhD
Universite Catholique De Louvain
Brussels,
Belgium
Molecular Landscape and Classification of Vascular Anomalies
Alexandra JaneBorst,MD
The Children's Hospital of Philadelphia
Philadelphia,
PA
Targeted Medical Therapies for Vascular Anomalies
Shelley ECrary,MD, MS
Arkansas Children's Hospital
Little Rock,
AR
Hemostasis and Thrombosis Risks and Management in Vascular Anomalies
ѻý Spotlight Sessions
Gene Therapy and Hemophilia A: What Is the Future of Curative Therapy in the Age of Emicizumab?
There have been marked advancements in the treatment of hemophilia A over the past decades. Adoption of routine prophylaxis to prevent bleeding as the standard of care has led to many children growing into adulthood with normal joint function and adults with improved function and quality of life. However, there remains a continued treatment burden and bleeding events, including spontaneous hemorrhage. Newer therapeutics with regulatory approval and in late phase clinical trial may further decrease the treatment burden and improve efficacy. This session will provide an update on gene therapy for hemophilia and discuss gene therapy in the context of new and coming therapies.
Frank W.G. Leebeek, MD, PhD
The Promise of Gene Therapy for Severe Hemophilia A
In the past decade enormous improvements have been made in delivering AAV-based gene therapy in patients with hemophilia A. In several phase 1 and 3 studies patients reached normal levels of FVIII after a single dose of AAV-delivered FVIII-gene construct, leading to reduced bleeding rates and patients could stop regular FVIII prophylaxis. During follow up of more than five years FVIII activity declined over time, however the majority of patients still have residual FVIII expression enabling them to refrain for prophylaxis. These promising results led to FDA and EMA approval of gene therapy for hemophilia A in 2022. Longer term follow-up is needed to show us the duration of benefits and (potential) drawbacks of gene therapy compared to current and other novel treatments.
Christine L Kempton, MD, MSc
Unknowns of Gene Therapy and Successes of Medical Therapies for Hemophilia A
Although gene therapy has held the promise of a cure, a consistent cure has yet to be realized. Additionally, the beneficial results seen in hemophilia A gene therapy clinical trials have occurred with meaningful challenges. This talk will review the risks and benefits of gene therapy for hemophilia A and consider them within the context of therapies (emicizumab and Fc-VWF-XTEN fusion protein-eht) that have shown consistent benefit compared with previously available factor VIII products as well as other promising therapies (Mim8, fitusiran, concizumab, and marstacimab) in late-stage clinical trials.
Chair:
Barbara A.Konkle,MD
Bloodworks Northwest
Seattle,
WA
Speakers:
Frank W.G. W.G.Leebeek,MD, PhD
Erasmus university Medical Center
Rotterdam,
Netherlands
The Promise of Gene Therapy for Severe Hemophilia A
Christine LKempton,MD,MSc
Emory University
Atlanta,
GA
Unknowns of Gene Therapy and Successes of Medical Therapies for Hemophilia A
Scientific Program
JOINT SESSION: Newly Described Functions in the Vascular Space
Scientific Committee on Megakaryocytes and Platelets + Scientific Committee on Thrombosis and Vascular Biology
Dysregulated interactions between platelets, immune cells, endothelial cells, and their plasma environment underlie numerous age-related diseases. This joint session will provide an integrated view of the vascular space and will highlight the cellular and molecular mechanisms underlying diseases that primarily afflict the elderly. Specifically, the session will also on novel discoveries addressing how platelet and endothelial aging may affect neurodegenerative disorders and thrombotic disease, and immune thrombocytopenia (ITP), and will shed light into the role of fibrinolytic factors in shaping the pro-atherogenic plasma lipid profile.
Dr. Claus Nerlov, will discuss how aging affects hematopoietic stem cells (HSCs). He will describe how increased HSC platelet bias due to how age-related increases in TGFbeta signaling is an evolutionarily conserved feature of murine and human hematopoiesis. The role of HSC platelet bias in suppressing lymphoid cell production during aging and how TGFbeta receptor inhibition can increase the ability of aged HSCs to support antiviral immunity will also be discussed.
Dr. Nichola Cooper, will discuss the current understanding of ITP pathogenesis and how the results from novel treatments in ITP may depict different disease types in ITP. ITP is a common bleeding disorder with an increase in incidence after age 60. Understanding the disease phenotype and evolution is needed to improve patient outcomes. However, the diagnosis remains presumptive, and treatment is largely empiric, with many patients rotating through several treatments before having a platelet response.
Dr. Lisa Lesniewski will discuss the phenotype of the aging vasculature and the hematopathology underlying mechanisms and potential therapeutic strategies being explored to reverse arterial aging to reduce cardiovascular (CVD) risk in older adults. This is important since several factors contributing to dysfunction of the endothelium (i.e., oxidative stress and inflammation, deregulated nutrient sensing, and cellular senescence) increase with aging and could impact CVD risk.
Dr. Ze Zheng will discuss research demonstrating that hepatocytes are an unappreciated source of tissue-type plasminogen activator (tPA), sense metabolic stresses, and impact the production of tPA and its inhibitor PAI1, thereby influencing the extent of fibrinolysis in obesity. She will introduce findings that tPA binds directly to hepatocyte apoB, preventing it from being loaded with lipids and assembled into lipoproteins. Conversely, tPA's inhibitor, PAI1, has the opposite effect, sequestering free tPA and preventing its interaction with apoB to promote VLDL assembly and increase apoB-lipoprotein cholesterol levels.
CoChair:
Speakers:
ܲDZ,ʳ
University of Oxford
Oxford,
United Kingdom
Platelets and Aging
DZǴDZ,Ѷ
Imperial College
London,
ENG,United Kingdom
New Insights in MK/PLT Functions and Diseases.
Ծɲ쾱,ʳ
University of Utah Health
Salt Lake City,
UT
Age-Related Endothelial Function
ܱܳԲ,ѵ,ʳ
Medical College of Wisconsin; Versiti Blood Research Institute
Milwaukee,
WI
Novel Functions of Fibrinolytic Factors in Shaping the Pro-Atherogenic Lipid Profile in Plasma.
Paradigm Shifts in Hemostasis: From Mechanisms to Therapies and Back
Scientific Committee on Hemostasis
Coagulation is not a linear process that ends at clot formation. Rather, coagulation is a network of ever-growing complexity with many mechanisms and pathways for regulation and feedback. The consequences of coagulation extend well beyond clot formation and into processes related to immunity, inflammation, vascular biology and regeneration. This session will highlight three examples for how bi-directional interactions from bench to bedside and back have paved the way to paradigm shifts in mechanistic insights, diagnosis, and treatment options for bleeding disorders and thrombotic complications.
Dr. Annette von Drygalski will discuss the most recent therapeutic paradigms in hemophilia. The continued unraveling of genetic and biochemical mechanisms underlying impaired blood clotting remains critical to inform the development of groundbreaking therapeutic strategies for Hemophilia A and B. Such strategies include extended half-life clotting factor preparations, non-factor-based molecules modifying hemostasis and, lastly, gene therapy. The new therapies have great potential to improve joint bleed prevention and reduce the sequelae of hemophilic arthropathy, which remains one of the most prominent aspects of clinical management in daily practice. Dr. von Drygalski will discuss pathophysiological mechanisms contributing to hemophilic arthropathy, new imaging modalities and joint outcome measures, paving the way for more targeted and individualized treatment strategies.
Dr. Daniël Verhoef will discuss the discovery and (pre)clinical development of a modified [PR1] recombinant form of coagulation factor X, called VMX-C001, which can bypass factor Xa direct oral anticoagulants (DOACs) in patients requiring immediate reversal of anticoagulation. It carries a unique 16 amino acid insertion that was derived from a snake venom factor X that makes VMX-C001 insensitive to inhibition by FXa DOACs. A single intravenous administration of VMX-C001 was shown to restore coagulation assays in animals and human volunteers on FXa-DOACs. VMX-C001 also prevented rivaroxaban induced bleeding in a primate liver injury model. VMX-C001 holds promise as an effective FXa DOAC reversal agent given its favorable half-life, short infusion time, FXa DOAC independent dosing and lack of a prothrombotic effect.
Dr. Cristina Puy will present a comprehensive exploration of coagulation factor XI dynamic interaction with diverse ligands, substrates, and endothelial cell receptors. Delving into the intricate mechanisms, Dr. Puy will elucidate factor XI pivotal role in modulating endothelial cell permeability and barrier function, shedding light on its implications in thrombotic and inflammatory conditions. This presentation will deepen our understanding of factor XI multifaceted involvement in health and disease.
Chair:
Laurent O.Mosnier,PhD
The Scripps Research Institute
La Jolla,
CA
Speakers:
Annettevon Drygalski,MD, PharmD, RMSK
University of California San Diego (UCSD)
SAN DIEGO,
CA
Paradigm Shifts in Hemophilia.
DaniëlVerhoef,MSc, PhD
VarmX B.V.
Leiden,
Netherlands
Paradigm Shifts in the Reversal of DOACs
CristinaPuy Garcia,PhD
Oregon Health and Science University
Portland,
OR
New Mechanisms That May Fuel the Paradigm Shifts of the Future
Understanding the Impact of Donor and Recipient Metabolic Variability on Blood Transfusion Outcomes
Scientific Committee on Transfusion Medicine
Blood transfusion requires the donation of blood products from a diverse array of individuals with unique genetics and environmental inputs. This results in the quality and overall behavior of the blood products being less standardized and predictable, with direct consequences on transfused recipients. This session will focus on how recently recognized unique genetic and environmental backgrounds of both the blood donor and the transfusion recipient influence the outcomes of patients. Newly applied metabolic tools reveal metabolic variability in donors and recipients, shedding light on fundamental aspects of these differential responses of transfusion in patients, which could guide future strategies for more personalized and effective blood transfusions.
Chair:
Cassandra DorothyJosephson,MD
Johns Hopkins All Children’s Hospital
St. Petersburg,
FL
Speakers:
Բ'Ի,ʳ
University of Colorado Anschutz Medical Campus
Aurora,
CO
Blood Donor Genetics and Biology Impact Red Blood Cell Transfusion Outcomes
ѴǰٳٴDZ,Ѷ
Bloodworks and University of Washington, Pathology and Laboratory Medicine
Seattle,
WA
Unveiling Platelet Metabolism: Implications for Storage and Transfusion
Dz,ʳ
Laboratory of Blood-Borne Parasites, Lindsley F. Kimball Research Institute, New York Blood Center
New York,
NY
Impact of RBC Metabolism on the Disease Outcomes of Transfusion Dependent Patients
Scientific Spotlight Sessions
Iron at the Crossroads Between Erythropoiesis and Megakaryopoiesis
This session will highlight the importance of iron balance for a healthy and effective erythropoiesis and thrombopoiesis. All mammalian cells rely on iron for normal functioning, with the erythropoietic compartment consuming the majority given the high iron requirements for hemoglobin synthesis. Recent evidence on the crosstalk between erythropoiesis and iron metabolism shed light on the consequences of insufficient as well as excess iron and heme on erythroid lineage proliferation and differentiation. In this session, the contribution of heme and iron excess to ineffective erythropoiesis will be described, with a focus on erythroid cell trajectories during differentiation, metabolic shifts, and erythroid cell-macrophage interaction within erythroblastic islands (EBIs). The session will also describe the role iron plays in other hematopoietic processes, including megakaryopoiesis and platelet formation.
CoChair:
Speakers:
Janis L.Abkowitz,MD
University of Washington
Seattle,
WA
Role of Heme and Iron in Effective and Ineffective Erythropoiesis
Radek C.Skoda,MD
University Hospital Basel
Basel,
Switzerland
Impact of Iron Availability on Megakaryopoiesis
Scientific Symposia
Interface of Complement and Coagulation
The complement system and coagulation pathways are the main pillars of immunity and hemostasis respectively that undergo significant activation with injury. While appearing distinct, it is recognized that significant crosstalk exists between the two systems and recently established molecular mechanisms provide insights into a wide variety of disorders. This session will focus on new molecular links identified in complement activation in specific and highly relevant clinical disorders.
Chair:
ٲԲ,ʳ
New Castle University
Newcastle Upon Tyne,
United Kingdom
Speakers:
ٲԲ,ʳ
New Castle University
Newcastle Upon Tyne,
United Kingdom
Complement and the Prothrombotic State
EfthymiaVlachaki,MD, PhD
Hippokrateon Hospital
Thessaloniki,
Greece
Complement Activation and Preclampsia
Lubka TRoumenina,PhD
INSERM UMRS1138 Cordeliers Research Center
Paris,
France
Sickle Cell Disease and Complement Activation
Interrogating the Impact of the Intestinal Microbiome on Transplant and Cellular Therapies
Fundamental advances have been achieved in the treatment of patients with hematologic malignancies through transplant and cellular therapy (TCT), including hematopoietic cell transplant and chimeric antigen receptor (CAR) T cell therapy. However, the therapies have limitations, such as relapses and toxicity. TCT outcomes have been associated with the intestinal microbiome. This session will focus on the intestinal microbiome in relation to TCT, from correlative research to interventional studies.
Chair:
ѱǻٳ,Ѷ,ѳ
Stanford University School of Medicine
Stanford,
CA
Speakers:
FlorentMalard,M.D., Ph.D.
Sorbonne Université, Hôpital Saint-Antoine, AP-HP, Service d'Hématologie Clinique et Thérapie Cellulaire,Centre de Recherche Saint-Antoine UMRs938
Paris,
France
Fecal Microbiota Transplant As a Strategy to Mitigate Infection and Gvhd Following TCT
Lawrence ADavid,PhD
Duke University
Durham,
NC
Deciphering Nutritional Intake from Metagenomic Data Using Computational Tools
ձԻԲ,Ѷ,ѱʱ
University of North Carolina, Chapel Hill
Chapel Hill,
NC
Impact of Antibiotic Exposure on Outcomes Following TCT
Newly Discovered Functions of Megakaryocytes and Platelets
This session will reveal new mechanisms of diseases related to platelet formation and function. Specifically, it will address glycosylation in megakaryocytes (Mks)/platelet functions and diseases; and highlight new insights in thromboinflammation, functions, and diseases of Mks and platelets.
Chair:
ԻܾԾ,Ѷ
Tufts University
Medford,
MA
Speakers:
Karin M.Hoffmeister,M.D.
Versiti Blood Research Institute, Milwaukee, WI
Milwaukee,
WI
Glycans and New Pathogenic Mechanisms of ITP
մDzʱٳDZ,Ѷ,ѳ
Charité – Universitätsmedizin Berlin
Berlin,
Germany
Regulation of Platelet Function During Immobilty
Anna S.Nam,MD
Weill Cornell Medicine
New York,
NY
Platelet ER Stress in Thrombosis
Special Symposium on the Basic Science of Hemostasis and Thrombosis
This session will highlight emerging topics and the latest discoveries in regulating inflammation at the cross-section of hemostasis, platelets, and vascular biology.
CoChair:
Speakers:
YesimDargaud,MD, PhD
Hopital Edouard Herriot Pav. E
Lyon,
France
Efficacy of Platelet-Inspired Hemostatic Nanoparticles on Bleeding in Von Willebrand Disease Murine Model
羱Բܳ,ʳ
Versiti Blood Research Institute
Milwaukee,
WI
Platelet Integrin Structure, Function and Role in Disease
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Qilu Hospital, Cheeloo College of Medicine, Shandong University
Jinan,
CHN
Platelet TGFb1 in the Pathogenesis of Immune Thrombocytopenia Purpura
Special-Interest Sessions
ASH Clinical Practice Guidelines on Pediatric Venous Thromboembolism (VTE)
This session will highlight new and revised recommendations for the treatment of VTE in pediatric patients, including addressing asymptomatic VTE, duration of therapy for provoked and unprovoked VTE, and use of anticoagulants.
Chair:
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University of Melbourne Royal Children's Hospital
Parkville,
VIC,Australia
Speakers:
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Children's Hospital of Philadelphia
Philadelphia,
PA
Why Revise the Guidelines?
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Lurie Children's Hospital
Chicago,
IL
Asymptomatic VTE in Pediatric Patients
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Johns Hopkins All Children's Hospital
Saint Petersburg,
FL
Duration of Therapy for Provoked and Unprovoked VTE in Pediatric Patients
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The Newcastle upon Tyne Hospitals NHS Trust
Newcastle Upon Tyne,
ENG,United Kingdom
Use of Anticoagulants in Children
Systems-Based Hematology ѻý and Networking Session: Anticoagulation Stewardship and AI-Assisted Management
This session will feature two talks on systems-level approaches to anticoagulation management, followed by a networking session where attendees will meet with the speakers and with established systems-based hematologists over light hors d'oeuvres and drinks. The first talk with feature Dr. Greg Barnes discussing how to improve systems-level management of anticoagulants within and across care settings. For the second talk, Dr. Damon E. Houghton will discuss the use of artificial intelligence (AI) and machine learning (ML) in the context of anticoagulation management.
Chair:
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Miami Cancer Institute
Miami,
FL
Speakers:
Geoffrey DBarnes,MD, MSc
University of Michigan
Ann Arbor,
MI
Improving Systems-Level Management of Anticoagulants Within and Across Care Settings
Damon E.Houghton,MD,MS
Mayo Clinic Rochester
Rochester,
MN
Artificial Intelligence (AI) and Machine Learning (ML) in the Context of Anticoagulation Management
Trainee Activities and Services
Career Development Lunch
This session provides an intimate venue for trainees to meet with leaders in hematology to discuss careers in the wide array of practice areas within hematology, including basic, clinical, and translational research, PhD careers, careers in industry settings, and careers in private and clinical practice. There will are multiple tables dedicated to each career area and one faculty member at each table leading the discussion. A boxed lunch is provided. This is a first come, first served event that is usually very-well attended. The full list of topics covered are: Adult BMT; Pediatric BMT; Adult Clinical Malignant Hematology; Adult Clinical Classical Hematology; Clinical Careers in Hematology (Private Practice Careers); Government Careers (NIH and FDA); Industry Careers; Laboratory and Translational Hematology; Medical Educators in Hematology; Pediatric Clinical Hematology; PhD careers; Systems-Based Hematology; Global Hematology; Maternal Health; Medical Informatics and AI; Lifespan; and Geriatric Hematology.
Chair:
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Moffitt Cancer Center
Lutz,
FL
Yvonne A.Efebera,MD
Ohio Health
Columbus,
OH
Rakhi P.Naik
,MD
Johns Hopkins Hospital
Baltimore,
MD
Hematology-Focused Fellowship Training Program (HFFTP)
Dzٱ
Dana-Farber Cancer Institute, Inc.
Boston,
MA
Hematology-Focused Fellowship Training Program (HFFTP)
PallawiTorka
,MD
Roswell Park Comprehensive Cancer Center
Buffalo,
NY
International Graduate Hematology
ShrutiChaturvedi
,MBBS
Johns Hopkins University School of Medicine
Baltimore,
MD
International Graduate Hematology
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University of Nebraska
Omaha,
NE
Geriatric Hematology
Alexander ABoucher
,MD
University of Minnesota
Minneapolis,
MN
Lifespan Hematology
Matthew J.Maurer
,DSc
Mayo University
Rochester,
MN
Medical Informatics and AI
ܱԲ
University of Ulm
Berlin,
Germany
Medical Informatics & AI
PaulaJames
,MD, FRCPC
Queen's University
Kingston,
ON,Canada
Maternal Health
AliBazarbachi
,MD, PhD
American University of Beirut Medical Center
Beirut,
Lebanon
International Opportunities Hematology
KoheiHosokawa
,MD, PhD
Kanazawa University
Kanazawa,
Japan
International Opportunities Hematology
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University Health Network
Toronto,
ON,Canada
Systems Based Hematology
ShannonElf
,PhD
The University of Chicago
Chicago,
IL
PhD Careers
ParvathiRanganathan
,PHD
Ohio State University
Columbus,
OH
PhD Careers
SaraVesely
,PhD
The Univ. of OK Health Sciences Ctr.
Oklahoma City,
OK
Pediatric Clinical Hematology
Angela CWeyand
,MD
University of Michigan Medical School
Ann Arbor,
MI
Pediatric Clinical Hematology
AndrewVolk
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Laboratory and Translational Hematology
SanjayMohan
,MD
Vanderbilt University Medical Center
Nashville,
TN
Medical Educators in Hematology
Tapan M.Kadia
,MD
MD Anderson Cancer Center
Houston,
TX
Medical Educators in Hematology
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Astra Zeneca
Potomac,
MD
Industry Careers
E. Leila JeromeClay
,MD
Johns Hopkins
Watertown,
MA
Industry Careers
Julie A.Panepinto
,MD, MSPH
Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute
Bethesda,
MD
Government Careers (NIH and FDA)
CaraRabik
,MD,PhD
Food and Drug Administration
Silver Spring,
MD
Government Careers (NIH and FDA)
Adrienne MHammill
,MD, PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
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Columbus Oncology and Hematology
Columbus,
OH
Private Practice Hematology
MariaCarter Febres
,MD
Cincinnati Children's Hospital
Cincinnati,
OH
Pediatric Hematology
Alfred ILee
,MD, PhD
Yale University School of Medicine
New Haven,
CT
Adult Classical Hematology
PayalDesai
,MD
Wake Forest University
Charlotte,
NC
Adult Classical Hematology
HannyAl-Samkari
,MD
Massachusetts General Hospital, Harvard Medical School
Boston,
MA
Adult Classical Hematology
SumithiraVasu
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult Malignant Hematology
BasemWilliam
,MD
OhioHealth Marion General Hospital
Columbus,
OH
Adult Malignant Hematology
²
Ohio State University Medical Center
Columbus,
OH
Adult Malignant Hematology
Nirali N.Shah
,MD
NIH
Bethesda,
MD
Pediatric BMT/CAR-T
RayneRouce
,MD
Texas Children's Hospital
Houston,
TX
Pediatric BMT/CAR-T
Abdullah MohammadKhan
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult BMT/Cellular Therapy
NareshBumma
,MD
The Ohio State University Comprehensive Cancer Center
COLUMBUS,
OH
Adult BMT/Cellular Therapy
Monique A.Hartley-Brown
,MD
DFCI
Boston,
MA
Adult BMT/Cellular Therapy
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MD Anderson Medical Center
Loma Linda,
TX
Pediatric BMT/CAR-T
Mikkael A.Sekeres
,MD
University of Miami Miller School of Medicine
Miami,
FL
Adult Malignant Hematology
OyebimpeAdesina
,MD,MS
UC Davis Comprehensive Cancer Center
Sacramento,
CA
Adult Classical Hematology
YiZheng
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
StevenFein
,MD,MPH
University of Miami
Miami,
FL
Private Practice Hematology
Elaine S.Jaffe
,MD
National Cancer Institute, National Institute of Health
Bethesda,
MD
Government Careers (NIH and FDA)
Ѳܻ
Bristol Myers Squibb
Madison,
NJ
Industry Careers
Alisa SWolberg
,PhD
University of North Carolina at Chapel Hill
Chapel Hill,
NC
Laboratory and Translational Hematology
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National Institutes of Health
Seattle,
WA
Medical Educators in Hematology
Sarah H.O'Brien
,MD,MSc
Ohio State University
Columbus,
OH
Pediatric Clinical Hematology
MargaretGoodell
,PhD
Center for Cell and Gene Therapy, Baylor College of Medicine
Houston,
TX
PhD Careers
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University of California
Oakland,
CA
Systems Based Hematology
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Baskent University
Ankara,
Turkey
International Opportunities Hematology
LisaBaumann Kreuziger
,MD, MS
Versiti
Milwaukee,
WI
Maternal Health
James S.Blachly
,MD
The Ohio State University
Columbus,
OH
Medical Informatics & AI
RebeccaKruse-Jarres
,MD,MPH
University of Washington
Seattle,
WA
Lifespan Hematology
AshleyRosko
,MD
The Ohio State University
Columbus,
OH
Geriatric Hematology
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Baptist Health South Florida
Miami,
FL
International Graduate Hematology
Hemoglobinopathies
ѻý Program
Challenges and Opportunities of Sickle Cell Care in Africa
This session will discuss the current state of therapies for sickle cell disease in Africa. Access barriers to disease-modifying and curative treatments for sickle cell anemia will be identified, and recommendations of strategies to address some of these barriers will be proposed. The case will be made to prioritize widespread use of hydroxyurea therapy as the bedrock of sickle cell anemia care in Africa.
Chair:
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The Hospital for Sick Children (SickKids) and the University of Toronto
Toronto,
ON,Canada
Speakers:
Obiageli ENnodu,MD
University of Abuja
Abuja,
Nigeria
Newborn Screening Initiatives for Sickle Cell Disease in Africa
岹
The Hospital for Sick Children (SickKids) and the University of Toronto
Toronto,
ON,Canada
Transfusion, Disease-Modifying Treatments, and Curative Therapies for Sickle Cell Disease in Africa: Where Are We Now?
Kofi A.Anie
London North West University Healthcare NHS Trust and Imperial College London
London,
ENG,United Kingdom
The Intersection of Sickle Cell Disease, Stigma, and Pain in Africa
Hematologic Challenges at the End-of-Life
Management of hematologic conditions for patients at the end of life is both a challenge and an opportunity to provide evidence-based, compassionate care. Care of seriously ill patients entails specific considerations—including incorporating life expectancy, addressing symptom burden, and navigating hospice—that apply across the spectrum of hematologic diseases. Further, there is a growing, multidisciplinary evidence base to support treatment decision-making that this session will review. First, we will discuss optimization of end-of-life care in transfusion-dependent hematologic malignancies. We will then focus on a strategy for management of anticoagulant medications in those with limited life expectancy. Finally, we will address prognostication and palliative care in sickle cell disease.
Dr. Loh will highlight challenges and barriers in implementing timely end-of-life-care and potential strategies to overcome these barriers for patients with transfusion-dependent hematologic malignancies.
Dr. Park's talk "Anticoagulation at the End of Life: Whether, When, and How to Treat," will focus on state-of-the-art evidence from hematology and palliative care science to inform management of anticoagulant medications in patients with life-limiting illness. Dr. Parks will discuss the complexities of anticoagulation at the end of life, opportunities to enhance our knowledge, and outline an approach to care that is based on patients’ values.
Dr. Johnston will discuss challenges in providing high quality end-of-life care for people with SCD, including disease-related, communication-related, and systemic-related challenges and discuss strategies to overcome these challenges, including use of primary and specialty palliative care.
Chair:
Anna L.Parks,MD
University of Utah Health
Salt Lake City,
UT
Speakers:
Kah Poh (Melissa)Loh,MD
University of Rochester
Rochester,
NY
Challenges in Hospice and End-of-Life Care in the Transfusion-Dependent Patient
Anna L.Parks,MD
University of Utah Health
Salt Lake City,
UT
Anticoagulation at the End of Life: Whether, When, and How to Treat
Emily EJohnston
University of Alabama At Birmingham
Birmingham,
AL
End-of-Life in the Sickle Cell Patient: Life Expectancy and the Role of Palliative Care
Integrating New Therapies into the Management of Classical Heme Disorders
This session will provide an overview on the current evidence of different novel therapies for the management of Classical Heme Disorders including ß-Thalassemia, Acute Intermittent Porphyria?(AIP) and anemia in chronic kidney disease (CKD).
Dr. Volker Haasewill outline mechanisms of action and pharmacologic properties of HIF-prolyl hydroxylase inhibitors (HIF-PHIs), a new class of oral anemia drugs approved for the use in patients with chronic kidney disease (CKD). He willdiscuss nondesirableon-target and off-target effects, cardiovascular and other safety concerns, and provide a benefit/risk-based perspective on how this new class of oral drugs might impact current management of anemia in CKD. A clinical case is presented that highlights the clinical complexities and therapeutic challenges in the management of anemia in patients with CKD.
Prof. Taher will highlight persisting unmet needs in patients with non-transfusion-dependent and transfusion-dependent ß-thalassemia. His presentation will overview the current evidence base for luspatercept as a novel disease-modifying agent targeting ineffective erythropoiesis in ß-thalassemia. He will also provide guidance on best-practices for practical application of luspatercept in the real world setting and identify emerging data gaps.
For Dr. Dickey’s presentation, she will review the givosiran clinical trial data and the available clinical literature on givosiran, as well as highlight important unanswered questions.
Chair:
Ali T.Taher,MD, FRCP
American University of Beirut Medical Center
Beirut,
Lebanon
Speakers:
Volker HansHaase
Vanderbilt University
Nashville,
TN
Hypoxia-Inducible Factor (HIF) Activators: ANovel Class of Oral Drugs for the Treatment of Anemia of Chronic Kidney Disease
Ali T.Taher,MD, FRCP
American University of Beirut Medical Center
Beirut,
Lebanon
Luspatercept: A Treatment for Ineffective Erythropoesis in Thalassemia
پ,Ѷ
Massachusetts General Hospital
Boston,
MA
Givosiran: A Targeted Treatment for Acute Intermittent Porphyria
Optimizing Non-Curative Therapies for Sickle Cell Disease
Despite expanding curative options, ineffective disease modifying medication use, acute pain management, and care delivery remain the primary challenges for the vast majority of individuals with sickle cell disease (SCD). This educational session will provide a practical guide for effectively using disease modifying medications, the best practices on delivering multi-modal acute pain management, and examples of successful, real-world adaptive clinical care models. Finally, it will discuss the remaining research questions to answer in these areas to optimize the outcomes of individuals with SCD.
Dr. Creary will discuss the disease modifying medications for SCD. The talk will offer practical guidance on how to overcome common treatment barriers and to use disease modifying medications in a way that balances the unique characteristics of these medications and the patients’ desired outcomes.
Dr. Brandow will discuss alternative methods for acute vaso-occlusive pain management. The talk will review recent research that support using non-opioid and non-pharmacologic interventions and the care delivery processes that have been shown to improve acute SCD pain outcomes
Dr. Bartolucci will discuss updating the existing clinical care models to be more personalized, adaptive, and collaborative, in response to the diverse experiences for those with SCD. The talk will discuss challenges in different income countries and the need for appropriate biomarkers and predictive algorithms.
Chair:
Susan ElizabethCreary,MD,MSc
Ohio State University College of Medicine
Columbus,
OH
Speakers:
Susan ElizabethCreary,MD,MSc
Ohio State University College of Medicine
Columbus,
OH
Practical Guide for Disease-Modifying Management of Children and Adolescents with SCD
Amanda M.Brandow,DO,MS
Medical College of Wisconsin
Milwaukee,
WI
Beyond IV Push: Alternative Methods for Management of Acute Pain in SCD
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APHP UPEC IMRB
Créteil,
France
Novel Clinical Care Models for Patients with Sickle Cell Disease
ѻý Spotlight Sessions
Curative Therapies for Sickle Cell Disease: Option for Some but Not Quite All
Despite substantial improvements in care, individuals with sickle cell disease continue to experience substantial morbidity and a shortened life expectancy.With recent advances in the development of curative therapies, including allogeneic stem cell transplantation and gene therapy, it is important to identify barriers to accessing these treatments and adequately define suitable candidates for curative therapies.
In this session, Dr. Santosh Saraf will review the current guidelines for curative therapies, discuss the potential benefits and risks of the different curative therapies, and provide insight on when to refer patients for curative therapy.
In the second presentation, Dr. Payal Desai will discuss the various barriers to accessing curative therapies as well as the need for development of an integrated care approach.
Chair:
Kenneth I.Ataga,MD
University of Tennessee Health Science Center
Memphis,
TN
Speakers:
Santosh L.Saraf,MD
University of Illinois Chicago
Chicago,
IL
Curative Therapies in Sickle Cell Disease: Which Patient, What Modality, and When to Refer
ʲⲹٱ,Ѷ
Wake Forest University
Charlotte,
NC
Systemic Barriers to Curative Therapy and Need for Integrated Care
Marquee Sessions
2024 Ham-Wasserman Lecture
Sickle cell disease (SCD) is an inherited red blood cell (RBC) disorder caused by either homozygous inheritance of the hemoglobin S mutation (HbSS), or compound heterozygous inheritance of the hemoglobin S mutation with another ß-globin chain abnormality. India has among the highest hemoglobin S allele frequencies in the world and the third-highest birth rate for babies born with HbSS.
The Indian sickle cell haplotype is associated with the Arab-Indian or Asian haplotype and is associated with high fetal hemoglobin (HbF) levels and hence, is believed to have mild clinical presentation as compared to other populations.
In this lecture Dr. Dipty Jain will discuss the status of frequency, comorbidities, and management of sickle cell disease (SCD) in India, which is characterized by relatively high percentages of fetal hemoglobin, accompanied by mild to severe complications observed globally. Additionally she will talk about targeted newborn screening and fixed low dose of hydroxyurea in managing children with sickle cell disease in India.
Dr. Jain will discuss the milestones and progress in understanding sickle cell disease (SCD) phenotype accelerated by the Government of India’s ambitious ‘’National Sickle Cell Anemia Elimination Mission 2023’’ with comprehensive guidelines and implementation of screening, treat, counsel, educate, development of technology and novel therapies including gene therapy specific to the requirement of India’s population with sickle cell disease (SCD).
Chair:
MohandasNarla,DSc
New York Blood Center
New York,
NY
Speaker:
Dipty LalitJain
Indira Gandhi Government Medical College and Hospital
NAGPUR,
India
Sickle Cell Disease in Developing Countries
2024 Presidential Symposium
Red cells constitute ~70% of all cells in the human body and in healthy individuals their circulatory life span is ~ 120 days. At steady state the bone marrow produces 2.5 million red cells per second to maintain normal hemoglobin levels. Anemia characterized by decreased hemoglobin levels is a major global health problem affecting nearly 2 billion individuals. Decreased red cell life span and/or decreased red cell production in the bone marrow account for anemia in various inherited and acquired hemolytic anemias. Significant progress has been and is continuing to be made in our understanding of the mechanistic basis for anemia. The three presentations in the symposium will highlight recent advances in our understanding of red cell biology and of anemia.
Dr. Patrick Gallagher will discuss recent advances which have expanded understanding of the many roles of the erythrocyte membrane. An update on the diagnosis and treatment of membrane disorders and potential emerging therapies will be discussed.
Dr. Naomi Taylor will highlight the pivotal role of metabolite transporters and fuel choice in erythroid lineage commitment and terminal erythroid differentiation. The importance of metabolic reprogramming in diseases of disordered and ineffective erythropoiesis will be discussed.
Dr. Olivier Hermine will explain the mechanisms that control red cell production during terminal erythroid differentiation, focusing on the processes that determine the fate of erythroid precursors between differentiation or cell death. The discussion will also touch upon how these mechanisms are impacted in hemoglobinopathies and myelodysplastic disorders, which can result in ineffective erythropoiesis and anemia. Additionally, therapeutic implications arising from these insights will be emphasized.
Chair:
MohandasNarla,DSc
New York Blood Center
New York,
NY
Speakers:
Patrick GGallagher,MD
Abigail Wexner Research Institute at Nationwide Children's Hospital
Columbus,
OH
Mature Red Cell Membrane Disorders (including genome-wide screening and PK activators)
NaomiTaylor,MD
National Institutes of Health
Bethesda,
MD
Metabolism and Erythropoiesis (including metabolism, IDH mutations and relevance to MDS, sideroblastic anemia)
OlivierHermine,MD,PhD
IMAGINE institute Paris France
Paris,
France
Ineffective Erythropoiesis in Thalassemia and Sickle Cell Disease
Ernest Beutler Lecture and Prize
Studies of hemoglobin, and its associated disorders, sickle cell disease (SCD) and the thalassemias, have written much of the history of the development of molecular biology and genetic medicine. More than 70 years ago, Dr. Linus Pauling dubbed SCD the first “molecular disease,” and seven years later Dr. Vernon Ingram identified the single amino acid difference between normal and sickle hemoglobin within the adult b-globin protein. With the advent of gene cloning and DNA sequencing, subsequent research in the 1980s elucidated the myriad mutations in the b-globin gene causing reduced or absent b-globin production in b-thalassemias. The benefits of increased expression of fetal hemoglobin (HbF) in individuals with SCD or b-thalassemia were recognized by astute clinicians based on of the lack of symptoms in the neonatal period and in the benign hereditary persistence of fetal hemoglobin (HPFH) condition. This stimulated interest in understanding the intricacies of globin gene regulation and how the switch from fetal (g)-to adult (b)-globin is normally controlled. In parallel, advances in gene transfer fueled efforts to introduce normal globin genes into hematopoietic stem cells of patients with mutant b-globin genes as curative therapy, an autologous approach built on decades of improvements in allogeneic bone marrow transplantation. Finally, remarkable advances in the modification of genes with CRISPR over the past decade have provided the means to define with precision the function of specific DNA sequences and develop gene editing approaches for therapy.
These research threads have converged to bring the first successive clinical trials forward for patients with SCD and b-thalassemia. In the last year, both globin gene addition (lovo-cel) and CRISPR gene editing (exa-cel) therapies received FDA approval. This lecture will describe the background and results of these groundbreaking studies, and discuss the challenges faced in bringing therapies to the many patients with SCD and b-thalassemia, particularly in resource-limiting geographic regions.
Dr. Stuart Orkin will describe current perspectives on the transcriptional control of globin genes, focusing on the direct role of the repressor protein BCL11A in silencing of HbF production and how CRISPR editing of an erythroid enhancer within the BCL11A gene forms the basis of the approved editing therapy, exa-cel, developed by CRISPR Therapeutics and Vertex Pharmaceuticals.
Dr. John Tisdale will summarize recent advances in ex vivo modification of hematopoietic stem cells for both lentiviral gene and CRISPR gene editing therapies for the hemoglobin disorders, concentrating on clinical parameters and prospects for improving preconditioning and moving toward strategies that would allow application without the need for hospitalization and intensive supportive care.
Chair:
MohandasNarla,DSc
New York Blood Center
New York,
NY
Speakers:
Stuart HOrkin,MD
Harvard Medical School
Boston,
MA
Basic Science
JohnTisdale,MD
National Institutes of Health
Bethesda,
MD
Clinical/Translational Science
Scientific Program
Ineffective Erythropoiesis: Insights Into Molecular Mechanisms and Disease Pathophysiology
Scientific Committee on Red Cell Biology
Ineffective erythropoiesis is the leading cause of red cell-related diseases, including anemia, which stands as the most prevalent hematologic disease, affecting millions of individuals worldwide. Understanding the underlying mechanisms of ineffective erythropoiesis is pivotal for advancing diagnostic and therapeutic approaches in hereditary anemias and adult-onset conditions. This session will explore recent breakthroughs in research related to ineffective erythropoiesis, focusing on areas of hemoglobinopathies, malaria infection, and myeloid neoplasms. By bringing together experts at the forefront of these investigations, the session will not only enhance understanding of the pathogenesis of ineffective erythropoiesis but also catalyze the development of innovative approaches to treat related diseases.
Chair:
PengJi,MD,PhD
Northwestern University Medical School
Chicago,
IL
Speakers:
WassimEl Nemer,PhD
French Blood Establishment (EFS)
Marseille,
France
Post-Transcriptional and Signaling Mechanisms in Ineffective Erythropoiesis in Hemoglobinopathies
Elizabeth S.Egan,MD, PhD
Stanford University School of Medicine
Stanford,
CA
Plasmodium Falciparum Influences Erythropoiesis
SergeiDoulatov,PhD
Division of Hematology, Department of Medicine
Seattle,
WA
Ineffective Erythropoiesis in Myeloid Neoplasms
Scientific Spotlight Sessions
Iron at the Crossroads Between Erythropoiesis and Megakaryopoiesis
This session will highlight the importance of iron balance for a healthy and effective erythropoiesis and thrombopoiesis. All mammalian cells rely on iron for normal functioning, with the erythropoietic compartment consuming the majority given the high iron requirements for hemoglobin synthesis. Recent evidence on the crosstalk between erythropoiesis and iron metabolism shed light on the consequences of insufficient as well as excess iron and heme on erythroid lineage proliferation and differentiation. In this session, the contribution of heme and iron excess to ineffective erythropoiesis will be described, with a focus on erythroid cell trajectories during differentiation, metabolic shifts, and erythroid cell-macrophage interaction within erythroblastic islands (EBIs). The session will also describe the role iron plays in other hematopoietic processes, including megakaryopoiesis and platelet formation.
CoChair:
Speakers:
Janis L.Abkowitz,MD
University of Washington
Seattle,
WA
Role of Heme and Iron in Effective and Ineffective Erythropoiesis
Radek C.Skoda,MD
University Hospital Basel
Basel,
Switzerland
Impact of Iron Availability on Megakaryopoiesis
Scientific Symposia
Interface of Complement and Coagulation
The complement system and coagulation pathways are the main pillars of immunity and hemostasis respectively that undergo significant activation with injury. While appearing distinct, it is recognized that significant crosstalk exists between the two systems and recently established molecular mechanisms provide insights into a wide variety of disorders. This session will focus on new molecular links identified in complement activation in specific and highly relevant clinical disorders.
Chair:
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New Castle University
Newcastle Upon Tyne,
United Kingdom
Speakers:
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New Castle University
Newcastle Upon Tyne,
United Kingdom
Complement and the Prothrombotic State
EfthymiaVlachaki,MD, PhD
Hippokrateon Hospital
Thessaloniki,
Greece
Complement Activation and Preclampsia
Lubka TRoumenina,PhD
INSERM UMRS1138 Cordeliers Research Center
Paris,
France
Sickle Cell Disease and Complement Activation
Interrogating the Impact of the Intestinal Microbiome on Transplant and Cellular Therapies
Fundamental advances have been achieved in the treatment of patients with hematologic malignancies through transplant and cellular therapy (TCT), including hematopoietic cell transplant and chimeric antigen receptor (CAR) T cell therapy. However, the therapies have limitations, such as relapses and toxicity. TCT outcomes have been associated with the intestinal microbiome. This session will focus on the intestinal microbiome in relation to TCT, from correlative research to interventional studies.
Chair:
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Stanford University School of Medicine
Stanford,
CA
Speakers:
FlorentMalard,M.D., Ph.D.
Sorbonne Université, Hôpital Saint-Antoine, AP-HP, Service d'Hématologie Clinique et Thérapie Cellulaire,Centre de Recherche Saint-Antoine UMRs938
Paris,
France
Fecal Microbiota Transplant As a Strategy to Mitigate Infection and Gvhd Following TCT
Lawrence ADavid,PhD
Duke University
Durham,
NC
Deciphering Nutritional Intake from Metagenomic Data Using Computational Tools
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University of North Carolina, Chapel Hill
Chapel Hill,
NC
Impact of Antibiotic Exposure on Outcomes Following TCT
Special-Interest Sessions
ASH Research Collaborative Data Hub Sickle Cell Disease Network: Accelerating Research and Collaborative Clinical Care through Real-World Evidence Generation
Session Description: During this 90-minute special-interest session, sickle cell disease (SCD) registry and real-world evidence (RWE) leaders will discuss progress across numerous SCD data initiatives, including the ASH Research Collaborative’s SCD Data Hub and other federal and non-federal programs. Specific topics include examples of using real-world data (RWD) to generate RWE, how RWD can be used to monitor clinical practice and outcomes for patients who receive cell and gene therapies, various approaches to ensuring data quality when using electronic health record data (EHR), federal priorities related to RWE generation that supports regulated research, and a new project to increased SCD-specific data standards within EHRs.
CoChair:
Speakers:
AlexisThompson,MD, MPH
Children's Hospital of Philadelphia
Philadelphia,
PA
Representing Sickle Cell Disease Health Concepts in Real World Evidence Generation: Examples from Real World Data (RWD) Initiatives and the Importance to the Sickle Cell Disease Community
PattySteinert,PhD,MBA
Medical College of Wisconsin
Milwaukee,
WI
The Role of RWD in Long-Term Follow-up of Cell and Gene Therapies in Sickle Cell Disease: The CIBMTR experience
SophieLanzkron,MD
Thomas Jefferson University
Baltimore,
MD
Challenges in Data Quality: Where EHR Data Acquisition Approaches and Highly-Curated Datasets Intersect (1)
AshimaSingh,PhD,MS
Medical College of Wisconsin
Pewaukee,
WI
Challenges in Data Quality: Where EHR Data Acquisition Approaches and Highly-Curated Datasets Intersect (2)
NicoleVerdun,MD
FDA
Silver Spring,
MD
Regulatory Perspective: Why RWD is Critical for Evaluation of SCD Disease Modifying Curative Therapies
LaVernePerlie,MSN, BSN, RN
Health and Human Services
Washington,
DC
Bringing It All Together: How the Federal Government Is Facilitating Collaboration across the Sickle Cell Data Landscape
Center for Sickle Cell Disease Initiatives: Advancing Progress in Sickle Cell Disease Update and Reception: hosted by ASH and ASH Research Collaborative
All meeting attendees interested in sickle cell disease are invited to attend the Center for Sickle Cell Disease Initiatives: Advancing Progress in Sickle Cell Disease Update and Reception. ASH is continuing its keen focus on the sickle cell disease initiative through the newly established ASH Center for Sickle Cell Disease Initiatives. This new Center will bring greater focus and cohesion to advancing our SCD initiatives. The Center is enhancing our ability to coordinate, track, and manage the wide range of responsibilities for this strategic initiative. The Center is focused on: Convening multidisciplinary partners and collaborators, promoting access to high quality care, global issues, policy and advocacy, research, and leveraging data. Please join us for an evening of networking and learn about this year's accomplishments.
Sickle Cell Disease Centers Session
To ensure high-quality care for patients with sickle cell disease (SCD), it is imperative that providers and SCD care leaders have the tools to establish comprehensive clinical care centers for patients with SCD. Over the last several years, ASH has developed a program and blueprint for the creation of sickle cell disease centers. This special interest session to address how sickle cell disease care centers can leverage the recent, relevant changes in quality metrics to deliver high quality care and demonstrate the financial value of centers to institutional leaders.
CoChair:
Symposium on Quality: Treating Fairly - The Role of Quality Improvement in Combating Health Care Disparities
This year's Quality Symposium will focus on practical strategies for combatting healthcare disparities. First, Dr. Melissa Creary will discuss the Michigan Social Health Interventions to Eliminate Disparities (MSHIELD) program, a statewide data-driven, community-partnered, and equity-centered quality improvement effort. Then Dr. Michelle Sholzberg will review the development and impact of the "Raise the Bar" project, which aims to eliminate disparities in the recognition and management of iron deficiency by adjusting reference ranges. The session will conclude with a talk by Dr. Thomas Greg Knight on mitigating the impact of financial toxicity in patients with hematologic malignancies.
CoChair:
Speakers:
MelissaCreary
University of Michigan School of Public Health
Ann Arbor,
MI
MSHIELD - Michigan Social Health Interventions to Eliminate Disparities
MichelleSholzberg,MDCM, MSc
University of Toronto
Toronto,
ON,Canada
Raise the Bar - Combatting Disparities in the Recognition and Management of Iron Deficiency
Thomas G.Knight,MD
Atrium Health
Charlotte,
NC
Cancer and Poverty - Mitigating the Impact of Financial Toxicity in Patients with Hematologic Malignancies
Trainee Activities and Services
Career Development Lunch
This session provides an intimate venue for trainees to meet with leaders in hematology to discuss careers in the wide array of practice areas within hematology, including basic, clinical, and translational research, PhD careers, careers in industry settings, and careers in private and clinical practice. There will are multiple tables dedicated to each career area and one faculty member at each table leading the discussion. A boxed lunch is provided. This is a first come, first served event that is usually very-well attended. The full list of topics covered are: Adult BMT; Pediatric BMT; Adult Clinical Malignant Hematology; Adult Clinical Classical Hematology; Clinical Careers in Hematology (Private Practice Careers); Government Careers (NIH and FDA); Industry Careers; Laboratory and Translational Hematology; Medical Educators in Hematology; Pediatric Clinical Hematology; PhD careers; Systems-Based Hematology; Global Hematology; Maternal Health; Medical Informatics and AI; Lifespan; and Geriatric Hematology.
Chair:
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Moffitt Cancer Center
Lutz,
FL
Yvonne A.Efebera,MD
Ohio Health
Columbus,
OH
Rakhi P.Naik
,MD
Johns Hopkins Hospital
Baltimore,
MD
Hematology-Focused Fellowship Training Program (HFFTP)
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Dana-Farber Cancer Institute, Inc.
Boston,
MA
Hematology-Focused Fellowship Training Program (HFFTP)
PallawiTorka
,MD
Roswell Park Comprehensive Cancer Center
Buffalo,
NY
International Graduate Hematology
ShrutiChaturvedi
,MBBS
Johns Hopkins University School of Medicine
Baltimore,
MD
International Graduate Hematology
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University of Nebraska
Omaha,
NE
Geriatric Hematology
Alexander ABoucher
,MD
University of Minnesota
Minneapolis,
MN
Lifespan Hematology
Matthew J.Maurer
,DSc
Mayo University
Rochester,
MN
Medical Informatics and AI
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University of Ulm
Berlin,
Germany
Medical Informatics & AI
PaulaJames
,MD, FRCPC
Queen's University
Kingston,
ON,Canada
Maternal Health
AliBazarbachi
,MD, PhD
American University of Beirut Medical Center
Beirut,
Lebanon
International Opportunities Hematology
KoheiHosokawa
,MD, PhD
Kanazawa University
Kanazawa,
Japan
International Opportunities Hematology
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University Health Network
Toronto,
ON,Canada
Systems Based Hematology
ShannonElf
,PhD
The University of Chicago
Chicago,
IL
PhD Careers
ParvathiRanganathan
,PHD
Ohio State University
Columbus,
OH
PhD Careers
SaraVesely
,PhD
The Univ. of OK Health Sciences Ctr.
Oklahoma City,
OK
Pediatric Clinical Hematology
Angela CWeyand
,MD
University of Michigan Medical School
Ann Arbor,
MI
Pediatric Clinical Hematology
AndrewVolk
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Laboratory and Translational Hematology
SanjayMohan
,MD
Vanderbilt University Medical Center
Nashville,
TN
Medical Educators in Hematology
Tapan M.Kadia
,MD
MD Anderson Cancer Center
Houston,
TX
Medical Educators in Hematology
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Astra Zeneca
Potomac,
MD
Industry Careers
E. Leila JeromeClay
,MD
Johns Hopkins
Watertown,
MA
Industry Careers
Julie A.Panepinto
,MD, MSPH
Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute
Bethesda,
MD
Government Careers (NIH and FDA)
CaraRabik
,MD,PhD
Food and Drug Administration
Silver Spring,
MD
Government Careers (NIH and FDA)
Adrienne MHammill
,MD, PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
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Columbus Oncology and Hematology
Columbus,
OH
Private Practice Hematology
MariaCarter Febres
,MD
Cincinnati Children's Hospital
Cincinnati,
OH
Pediatric Hematology
Alfred ILee
,MD, PhD
Yale University School of Medicine
New Haven,
CT
Adult Classical Hematology
PayalDesai
,MD
Wake Forest University
Charlotte,
NC
Adult Classical Hematology
HannyAl-Samkari
,MD
Massachusetts General Hospital, Harvard Medical School
Boston,
MA
Adult Classical Hematology
SumithiraVasu
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult Malignant Hematology
BasemWilliam
,MD
OhioHealth Marion General Hospital
Columbus,
OH
Adult Malignant Hematology
²
Ohio State University Medical Center
Columbus,
OH
Adult Malignant Hematology
Nirali N.Shah
,MD
NIH
Bethesda,
MD
Pediatric BMT/CAR-T
RayneRouce
,MD
Texas Children's Hospital
Houston,
TX
Pediatric BMT/CAR-T
Abdullah MohammadKhan
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult BMT/Cellular Therapy
NareshBumma
,MD
The Ohio State University Comprehensive Cancer Center
COLUMBUS,
OH
Adult BMT/Cellular Therapy
Monique A.Hartley-Brown
,MD
DFCI
Boston,
MA
Adult BMT/Cellular Therapy
Ჹ
MD Anderson Medical Center
Loma Linda,
TX
Pediatric BMT/CAR-T
Mikkael A.Sekeres
,MD
University of Miami Miller School of Medicine
Miami,
FL
Adult Malignant Hematology
OyebimpeAdesina
,MD,MS
UC Davis Comprehensive Cancer Center
Sacramento,
CA
Adult Classical Hematology
YiZheng
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
StevenFein
,MD,MPH
University of Miami
Miami,
FL
Private Practice Hematology
Elaine S.Jaffe
,MD
National Cancer Institute, National Institute of Health
Bethesda,
MD
Government Careers (NIH and FDA)
Ѳܻ
Bristol Myers Squibb
Madison,
NJ
Industry Careers
Alisa SWolberg
,PhD
University of North Carolina at Chapel Hill
Chapel Hill,
NC
Laboratory and Translational Hematology
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National Institutes of Health
Seattle,
WA
Medical Educators in Hematology
Sarah H.O'Brien
,MD,MSc
Ohio State University
Columbus,
OH
Pediatric Clinical Hematology
MargaretGoodell
,PhD
Center for Cell and Gene Therapy, Baylor College of Medicine
Houston,
TX
PhD Careers
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University of California
Oakland,
CA
Systems Based Hematology
dz
Baskent University
Ankara,
Turkey
International Opportunities Hematology
LisaBaumann Kreuziger
,MD, MS
Versiti
Milwaukee,
WI
Maternal Health
James S.Blachly
,MD
The Ohio State University
Columbus,
OH
Medical Informatics & AI
RebeccaKruse-Jarres
,MD,MPH
University of Washington
Seattle,
WA
Lifespan Hematology
AshleyRosko
,MD
The Ohio State University
Columbus,
OH
Geriatric Hematology
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Baptist Health South Florida
Miami,
FL
International Graduate Hematology
Immune Disorders
ѻý Program
ALPS, CVID, and LGL: When Autoimmune Cytopenias Are a Marker of Underlying Immune Disease
Autoimmune cytopenias that are chronic, refractory and multi lineage present a challenge in the clinic. However, recent advances exploring their molecular genetic underpinnings have made them more amenable to rationally targeted therapies and forestall end organ damage in the long run. Dr. V. Koneti Rao will discuss diagnosis and management of ALPS-FAS (Autoimmune Lymphoproliferative Syndrome due to FAS variants) and APDS (Activated PI3Kinase Delta Syndrome due to PIK3CD and PIK3R1 genetic variants) including recently licensed targeted treatment for the latter using a PI3Kinsae inhibitor, leniolisib. Dr.Charlotte Cunnigham Rundles will discuss the impact of genetic disorders presenting as CVID (Common Variable Immune Deficiency) affecting multiple organs due to variants in transcription factors, check point inhibitors, chemokines and cytokines. CVID is one of the most common inborn errors of immunity presenting with infections due to insufficient levels of immune globulins and loss of specific antibodies. However, a significant proportion of these patients develop autoimmune multilineage cytopenias and increased susceptibility to malignancies including lymphoma. These conditions may often be the initial manifestation of the underlying immune defect in a patient who has not had significant infections, and these episodes may recur over time. Treatment of the hematologic complications may require frequent and episodic use of corticosteroids, and/or rituximab; splenectomy is discouraged. Genetic associations noted in CVID patients include CTLA4, LRBA, IKZF1, NFKB1 and NFKB2,STAT3 and STAT1 variants that might provide opportunities for targeted therapeutics. Dr.Thierry Lamy will highlight the impact of clonal evolution of T and Nk cells in LGL (large granular lymphocytosis).Large granular lymphocyte (LGL) leukemia is a rare T/NK cell driven chronic lymphoproliferative disease characterized by neutropenia, anemia and autoimmune disorders such as rheumatoid arthritis, Sjogren syndrome, vasculitis, and autoimmune endocrinopathies. Recent advances in the pathogenesis of LGL leukemia have highlighted the implication of STAT3 genetic variants playing a pivotal role in the leukemic cell proliferation and survival, and autoimmunity. The genetic landscape of LGL is afflicted with gene mutations affecting NF-KB pathway (TNFAIP3), epigenome (TET2, KMT2D), and microenvironment (CCL22). Immunosuppressive agents (cyclophosphamide, methotrexate and cyclosporine) constitute the foundation of first line therapy. Recent advances have led to the development of targeted approaches, including JAK-STAT inhibitors, cytokine targeting and hypomethylating agents, opening novel approaches in an otherwise incurable disease.
Chair:
V. KonetiRao,MD
National Institutes of Health
Bethesda,
MD
Speakers:
V. KonetiRao,MD
NIH
Bethesda,
MD
Beyond FAScinating: Advances in Diagnosis and Management of Autoimmune Lymphoproliferative Syndrome (ALPS)
CharlotteCunningham-Rundles,MD, PhD
Mount Sinai School of Medicine
New York,
NY
Common Variable Immunodeficiency (CVID): Hematologic Presentation and Advances in Molecular Diagnosis
ThierryLamy,MD, PhD
Pontchaillou Hospital Rennes UNIVERSITY HOSPITAL
Rennes,
France
Large Granular Lymphocytosis (LGL): A Clonal Disorder with Autoimmune Manifestations
HIT-and-Run: Challenges in Diagnosis and Management of Heparin-Induced Thrombocytopenia
In hospitalized patients, the diagnosis and management of heparin induced thrombocytopenia (HIT) is a recurrent challenge. To this end, this session will 1) provide evidence-based practical guidance in the diagnosis and management of suspected and confirmed HIT; 2) classify anti-platelet factor 4 (PF4) antibody mediated disorders (autoimmune HIT), their relationship to heparin exposure, and the role of rapid PF4 and platelet activation assays in diagnosis; and 3) review alternative management strategies when heparin cessation and non-heparin anticoagulants are insufficient in patients who have refractory HIT, experience acute bleeding, or are planned to undergo cardiac surgery. Emphasizing evidence-based strategies, this session will provide practical approaches and system-level interventions for high-quality care.
Chair:
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Duke University
Durham,
NC
Speakers:
Jori E.May,MD
University of Alabama at Birmingham
Birmingham,
AL
Practical Guide to Diagnosis and Management of “Typical” HIT(T)
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Duke University
Durham,
NC
Alternative Approaches to Management of HIT in Complex Scenarios, including Cardiac Surgery
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University College London
London,
ENG,United Kingdom
Demystifying Autoimmune HIT: What It Is, When to Test, and How to Treat
Not All Lymphadenopathy is Lymphoma: Lymphoproliferative Diseases of Immune Dysregulation
Immune dysregulation often causes lymphadenopathy that requires clinicopathological correlation for accurate diagnosis. This session will review important causes of lymphadenopathy that fall outside the typical spectrum of malignant lymphoma. Castleman disease, IgG4-Related disease and the relationship between EBV and Post-transplant Lymphoproliferative Disorder will be reviewed. A common theme among these sessions is the importance of combining clinical, laboratory, and pathological “clues” to arrive at the best possible diagnosis and management plan.
Dr. Fajgenbaum will provide an overview on the classification, diagnosis, and management of Castleman disease. Castleman disease is a heterogeneous group of lymphoproliferative disorders, and idiopathic multicentric Castleman disease (iMCD) can be particularly difficult to diagnose and distinguish from other inflammatory causes of lymphadenopathy. Diagnostic criteria for iMCD and the subtypes of iMCD including thrombocytopenia, anasarca, (reticulin) fibrosis, renal dysfunction and organomegaly (iMCD-TAFRO), idiopathic plasmacytic lymphadenopathy (iMCD-IPL) and not otherwise specified (iMCD-NOS) will be reviewed.
Dr. Chen will review IgG4-related disease (IgG4-RD), a disease of immune dysregulation with protean manifestations including autoimmune pancreatitis, sclerosing cholangitis, lacrimal and salivary gland swelling, and tubulointerstitial nephritis. The session will focus on an approach to four key manifestations for Hematologists: Polyclonal hypergammaglobulinemia, IgG4-positive plasma cell enriched lymphadenopathy, eosinophilia, and retroperitoneal fibrosis. Practical tips for differentiating IgG4-RD from key mimickers such as Castleman disease, eosinophilic vasculitis, and histiocyte disorders will be highlighted.
Dr. Rouce will discuss the interplay between Epstein-Barr virus (EBV) and Post-tranplant lymphoproliferative disorder (PTLD). The spectrum of PTLD includes three variations of lymphoproliferation: lymphoid hyperplasia, neoplasia and malignancy. Lymphoid hyperplasia is characterized by polyclonal proliferation and non-destructive lesions whereas lymphoid malignancy features monoclonal proliferation and destructive lesions. EBV is the main driver of PTLD, and management ranges from reduction in immunosuppression to intensive, lymphoma-directed therapy.
Chair:
Luke Y. C.Chen,MD,MEd
Dalhousie University
Halifax,
NS,Canada
Speakers:
David C.Fajgenbaum,MD, MBA, MSc
University of Pennsylvania
Philadelphia,
PA
Identifying Castleman Disease from Non-Clonal Inflammatory Causes of Generalized Lymphadenopathy
Luke Y. C.Chen,MD,MEd
Dalhousie University
Halifax,
NS,Canada
IgG-4 Disease for the Hematologist
RayneRouce,MD
Texas Children's Hospital
Houston,
TX
EBV and Post-transplant Lymphoproliferative Disorder (PTLD): A Complex Relationship
Trainee Activities and Services
Career Development Lunch
This session provides an intimate venue for trainees to meet with leaders in hematology to discuss careers in the wide array of practice areas within hematology, including basic, clinical, and translational research, PhD careers, careers in industry settings, and careers in private and clinical practice. There will are multiple tables dedicated to each career area and one faculty member at each table leading the discussion. A boxed lunch is provided. This is a first come, first served event that is usually very-well attended. The full list of topics covered are: Adult BMT; Pediatric BMT; Adult Clinical Malignant Hematology; Adult Clinical Classical Hematology; Clinical Careers in Hematology (Private Practice Careers); Government Careers (NIH and FDA); Industry Careers; Laboratory and Translational Hematology; Medical Educators in Hematology; Pediatric Clinical Hematology; PhD careers; Systems-Based Hematology; Global Hematology; Maternal Health; Medical Informatics and AI; Lifespan; and Geriatric Hematology.
Chair:
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Moffitt Cancer Center
Lutz,
FL
Yvonne A.Efebera,MD
Ohio Health
Columbus,
OH
Rakhi P.Naik
,MD
Johns Hopkins Hospital
Baltimore,
MD
Hematology-Focused Fellowship Training Program (HFFTP)
Dzٱ
Dana-Farber Cancer Institute, Inc.
Boston,
MA
Hematology-Focused Fellowship Training Program (HFFTP)
PallawiTorka
,MD
Roswell Park Comprehensive Cancer Center
Buffalo,
NY
International Graduate Hematology
ShrutiChaturvedi
,MBBS
Johns Hopkins University School of Medicine
Baltimore,
MD
International Graduate Hematology
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University of Nebraska
Omaha,
NE
Geriatric Hematology
Alexander ABoucher
,MD
University of Minnesota
Minneapolis,
MN
Lifespan Hematology
Matthew J.Maurer
,DSc
Mayo University
Rochester,
MN
Medical Informatics and AI
ܱԲ
University of Ulm
Berlin,
Germany
Medical Informatics & AI
PaulaJames
,MD, FRCPC
Queen's University
Kingston,
ON,Canada
Maternal Health
AliBazarbachi
,MD, PhD
American University of Beirut Medical Center
Beirut,
Lebanon
International Opportunities Hematology
KoheiHosokawa
,MD, PhD
Kanazawa University
Kanazawa,
Japan
International Opportunities Hematology
վܰپ
University Health Network
Toronto,
ON,Canada
Systems Based Hematology
ShannonElf
,PhD
The University of Chicago
Chicago,
IL
PhD Careers
ParvathiRanganathan
,PHD
Ohio State University
Columbus,
OH
PhD Careers
SaraVesely
,PhD
The Univ. of OK Health Sciences Ctr.
Oklahoma City,
OK
Pediatric Clinical Hematology
Angela CWeyand
,MD
University of Michigan Medical School
Ann Arbor,
MI
Pediatric Clinical Hematology
AndrewVolk
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Laboratory and Translational Hematology
SanjayMohan
,MD
Vanderbilt University Medical Center
Nashville,
TN
Medical Educators in Hematology
Tapan M.Kadia
,MD
MD Anderson Cancer Center
Houston,
TX
Medical Educators in Hematology
ٲԾմǷɲԲ
Astra Zeneca
Potomac,
MD
Industry Careers
E. Leila JeromeClay
,MD
Johns Hopkins
Watertown,
MA
Industry Careers
Julie A.Panepinto
,MD, MSPH
Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute
Bethesda,
MD
Government Careers (NIH and FDA)
CaraRabik
,MD,PhD
Food and Drug Administration
Silver Spring,
MD
Government Careers (NIH and FDA)
Adrienne MHammill
,MD, PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
ܱ
Columbus Oncology and Hematology
Columbus,
OH
Private Practice Hematology
MariaCarter Febres
,MD
Cincinnati Children's Hospital
Cincinnati,
OH
Pediatric Hematology
Alfred ILee
,MD, PhD
Yale University School of Medicine
New Haven,
CT
Adult Classical Hematology
PayalDesai
,MD
Wake Forest University
Charlotte,
NC
Adult Classical Hematology
HannyAl-Samkari
,MD
Massachusetts General Hospital, Harvard Medical School
Boston,
MA
Adult Classical Hematology
SumithiraVasu
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult Malignant Hematology
BasemWilliam
,MD
OhioHealth Marion General Hospital
Columbus,
OH
Adult Malignant Hematology
²
Ohio State University Medical Center
Columbus,
OH
Adult Malignant Hematology
Nirali N.Shah
,MD
NIH
Bethesda,
MD
Pediatric BMT/CAR-T
RayneRouce
,MD
Texas Children's Hospital
Houston,
TX
Pediatric BMT/CAR-T
Abdullah MohammadKhan
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult BMT/Cellular Therapy
NareshBumma
,MD
The Ohio State University Comprehensive Cancer Center
COLUMBUS,
OH
Adult BMT/Cellular Therapy
Monique A.Hartley-Brown
,MD
DFCI
Boston,
MA
Adult BMT/Cellular Therapy
Ჹ
MD Anderson Medical Center
Loma Linda,
TX
Pediatric BMT/CAR-T
Mikkael A.Sekeres
,MD
University of Miami Miller School of Medicine
Miami,
FL
Adult Malignant Hematology
OyebimpeAdesina
,MD,MS
UC Davis Comprehensive Cancer Center
Sacramento,
CA
Adult Classical Hematology
YiZheng
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
StevenFein
,MD,MPH
University of Miami
Miami,
FL
Private Practice Hematology
Elaine S.Jaffe
,MD
National Cancer Institute, National Institute of Health
Bethesda,
MD
Government Careers (NIH and FDA)
Ѳܻ
Bristol Myers Squibb
Madison,
NJ
Industry Careers
Alisa SWolberg
,PhD
University of North Carolina at Chapel Hill
Chapel Hill,
NC
Laboratory and Translational Hematology
ԻⲹʲԳ
National Institutes of Health
Seattle,
WA
Medical Educators in Hematology
Sarah H.O'Brien
,MD,MSc
Ohio State University
Columbus,
OH
Pediatric Clinical Hematology
MargaretGoodell
,PhD
Center for Cell and Gene Therapy, Baylor College of Medicine
Houston,
TX
PhD Careers
ǰʲ
University of California
Oakland,
CA
Systems Based Hematology
dz
Baskent University
Ankara,
Turkey
International Opportunities Hematology
LisaBaumann Kreuziger
,MD, MS
Versiti
Milwaukee,
WI
Maternal Health
James S.Blachly
,MD
The Ohio State University
Columbus,
OH
Medical Informatics & AI
RebeccaKruse-Jarres
,MD,MPH
University of Washington
Seattle,
WA
Lifespan Hematology
AshleyRosko
,MD
The Ohio State University
Columbus,
OH
Geriatric Hematology
첹Գٳ
Baptist Health South Florida
Miami,
FL
International Graduate Hematology
Lymphoid Malignancies
ѻý Program
A Little Less Conversation, a Little More Action: An Outcome Equity Roadmap for Children and AYAs With Leukemia and Lymphoma
Centuries of structural racism have contributed to discrimination, environmental and social injustice, and household material hardship among historically marginalized populations. Recent studies have highlighted the impact of factors such as income and insurance status on cancer outcomes and health equity. Under-representation of specific groups has limited our understanding of cancer risk, disease biology, treatment-related toxicities, and patient-reported outcomes. The educational objective of this session is to present the latest evidence regarding modifiable factors that contribute to outcome disparities in childhood/adolescent and young adult (AYA) hematologic malignancies, and to discuss potential targets for interventions that address these disparities. Dr. Ji will present an in-depth overview of public health insurance programs in the U.S. and related implications on outcome disparities among AYAs with blood cancers. Using a case-based approach, Dr. Ji will discuss opportunities to improve access to high-quality public health insurance, subsequent to the Affordable Care Act. Dr. Umaretiya will discuss the role of social determinants of health (SDOH) as modifiable drivers of outcome inequities in pediatric oncology. She will review the prevalence of SDOH in pediatric oncology, present historically marginalized parent perspectives on unmet social needs during cancer care, and highlight novel interventions addressing this population’s SDOH and social needs. Dr. Mittal will discuss factors contributing to low rates of enrollment of AYAs with hematologic malignancies to clinical trials, including a lack of availability and accessibility. She will provide an up-to-date review of collaborative initiatives that are addressing some of these barriers to improve AYA access to cancer clinical trials.
Chair:
Maria Monica MonicaGramatges,MD,PhD
Texas Children's Hospital
Houston,
TX
Speakers:
XuJi,PhD
Emory University School of Medicine
Atlanta,
GA
The Lasting Impact of the ACA: How Medicaid Expansion Reduces Outcome Disparities in AYAs With Leukemia and Lymphoma
Puja J.Umaretiya,MD
Childrens Medical Center Dallas, UT Southwestern
Dallas,
TX
Targeting Hardship: Poverty as a Modifiable Risk Factor in Childhood Leukemia and Lymphoma Treatment
Nupur MittalNupur Mittal
Rush University Medical Center
Chicago,
IL
Sharing is Caring: A Network Collaborative Approach to Identify and Address Barriers in Accessing Clinical Trials in AYAs with Leukemia and Lymphoma
A Shifting Landscape: Treatment of MCL
Mantle Cell Lymphoma is a rare subtype of B-cell non-Hodgkin Lymphoma characterized by disease heterogeneity. The approach to treating patients diagnosed with mantle cell lymphoma has evolved over time with therapeutics including high dose cytarabine containing regimens prior to autologous stem cell consolidation, rituximab maintenance and the oral Bruton’s tyrosine kinase inhibitors for relapsed/refractory disease. It is recognized that not all patients benefit from these approaches. This educational session will explore the evolving treatment landscape in mantle cell lymphoma including identification and treatment of patients with high-risk disease, the role of autologous stem cell transplant consolidation in the era of novel therapies and the current and future incorporation of T-cell engaging therapies in the treatment landscape.
Dr. Kami Maddocks will define high-risk features in Mantle Cell Lymphoma associated with inferior prognosis to standard treatment approaches. Clinical trials incorporating Bruton's tyrosine kinase inhibitors into initial therapy will be discussed. The role of targeted and immunotherapy combinations in a “chemotherapy-free” approach will be presented.
Dr. Martin Dreyling will discuss the role of autologous stem cell transplantation and additional consolidation/maintenance therapies in first line treatment. Clinical trials incorporating Bruton's tyrosine kinase inhibitors into initial therapy will be mentioned. Differential treatment strategies according to clinically applicable biological risk factors will be suggested.
Dr. Lia Palomba will review T-cell engaging therapies in relapsed or refractory Mantle Cell Lymphoma, including CAR T-cells and bispecific antibodies. She will review available data on the outcome of these therapies in the general MCL population and in high-risk subgroups.
Chair:
Kami J.Maddocks,MD
The Ohio State University
Columbus,
OH
Speakers:
Kami J.Maddocks,MD
The Ohio State University
Columbus,
OH
Your Chemo is No Good Here: Management of High-Risk MCL
MartinDreyling,MD
LMU University Hosptial München
Munich,
Germany
To Consolidate or Not to Consolidate – The Role of Autologous Stem Cell Transplantation in MCL
Maria LiaPalomba,MD
Memorial Sloan Kettering
New York,
NY
T-cell–based Therapies for Treating Relapsed or Refractory Mantle Cell Lymphoma
Addressing Unmet Needs in T Cell Lymphomas
The rare nature of peripheral and cutaneous T-cell lymphomas, variable clinical course and only recently evolving understanding of their unique biology make the care of patients with these disease particularly difficult. This educational session will delve into current clinical challenges in management of this difficult to treat population and will focus on the more common subtypes of peripheral T-cell lymphoma and cutaneous T-cell lymphomas. The session first will discuss management, incorporation of novel agents and consideration of personalized approaches in relapsed/refractory peripheral T-cell lymphomas and cutaneous T-cell lymphomas. We will also discuss the utility and timing of both autologous and allogeneic transplant in cutaneous and peripheral T-cell lymphoma.
Dr. Mehta-Shah will discuss current clinical challenges in the management of patients with relapsed/refractory T-cell lymphomas. In the evolving landscape of treatment and biologic considerations, we will discuss the use of both standard agents as well as novel targeted agents in the treatment of this patient population. Given that our understanding of these heterogenous diseases continues to improve, we will discuss strategies for subtypes specific or personalized therapy.
Dr. Horwitz will explore and detail the expanding options for treatment of CTCL.
Dr. Dreger will discuss the role of stem cell transplant (auto and allo) on PTCL and CTCL.
Chair:
NehaMehta-Shah,MD, MSCI
Washington University in St. Louis
St Louis,
MO
Speakers:
NehaMehta-Shah,MD, MSCI
Washington University in St. Louis
St Louis,
MO
BV and Beyond: How to Incorporate Novel Agents into PTCL Management
StevenHorwitz,MD
Memorial Sloan-Kettering Cancer Center
New York,
NY
Expanding Options for Treatment of CTCL
PeterDreger
ԾäٲԾܳ
Heidelberg,
Germany
The Role of Stem Cell Transplant (auto and allo) in PTCL and CTCL
Adult ALL Advancements: Optimizing Cure in 2024
Acute lymphoblastic leukemia (ALL) in adults is an aggressive condition with historically few long-term survivors. Fortunately, the outlook for ALL in adults is improving rapidly as years of scientific research and clinical investigation begins to pay dividends. Improved understanding of the heterogeneity and varied biological behavior of ALL subtypes has led to routine immunophenotypic and genetic characterization of individual ALL cases in the clinic. Profiling of ALL at diagnosis as well as better ability to track measurable residual disease (MRD) after therapy now permits personalized, risk-adapted treatment recommendations in ALL including the rational application of allogeneic stem cell transplantation. In addition, multiple new targeted and immune therapies have been approved by regulatory authorities for Philadelphia chromosome-positive (Ph+) and negative B-ALL. The rapid pace of scientific and therapeutic advancement in ALL is challenging established standards of care for upfront treatment of adults with newly diagnosed ALL. In this session, the impact of scientific and therapeutic advancements in the initial treatment approach for ALL will be reviewed, with a focus on recent evidence generation.
Dr. Marlise Luskin will review data supporting the selection of various approaches to initial treatment of Ph+ ALL in adults. She will discuss data justifying the use of specific BCR-ABL1 kinase inhibitors including dasatinib, nilotinib, and ponatinib. In this session, she will also review evidence defining the role of conventional chemotherapy, allogeneic transplantation, and the bi-specific T-cell engager (BiTE) blinatumomab in first-line post-remissiont treatment of Ph+ ALL in adults of different ages.
Prof. Matthias Stelljes will discuss the role of novel antibody-based and cell-based immunotherapies in the treatment of ALL in adults. Blinatumomab, the antibody-drug conjugate inotuzumab ozogamicin, and CD19-directed CAR-T cells are current standard-of-care options for patients with relapsed or refractory B-cell ALL. The CD20-targeting monoclonal antibody rituximab and blinatumomab are established components of frontline therapy for patients with CD20-positive ALL and patients with persistent MRD, respectively. More recently, blinatumomab and inotuzumabhave shown promising results in the upfront treatment of patients with B-cell ALL. These data form the basis for evaluating and defining new treatment standards, which will be discussed in this educational session.
Dr. Partow Kebriaei will review risk profiling in adult patients with ALL, and specifically how disease risk informs the decision to recommend transplant in first complete remission. Additionally, she will highlight advancements in GVHD prophylaxis that facilitate greater donor availability and decreased toxicity of transplant. Finally, Dr. Kebriaei will review the optimal sequence for transplant within the context of CAR T therapy.
Chair:
Marlise RLuskin,MD, MSCE
Dana-Farber Cancer Institute
Boston,
MA
Speakers:
Marlise RLuskin,MD, MSCE
Dana-Farber Cancer Institute
Boston,
MA
PH+ ALL: New Approaches for Upfront Therapy
MatthiasStelljes,MD
University Hospital Muenster
Muenster,
Germany
Ph- ALL: Impact of Immunotherapy in Upfront Treatment
PartowKebriaei,MD
MD Anderson Cancer Center
Houston,
TX
Transplant in ALL: Who, When, and How?
ALPS, CVID, and LGL: When Autoimmune Cytopenias Are a Marker of Underlying Immune Disease
Autoimmune cytopenias that are chronic, refractory and multi lineage present a challenge in the clinic. However, recent advances exploring their molecular genetic underpinnings have made them more amenable to rationally targeted therapies and forestall end organ damage in the long run. Dr. V. Koneti Rao will discuss diagnosis and management of ALPS-FAS (Autoimmune Lymphoproliferative Syndrome due to FAS variants) and APDS (Activated PI3Kinase Delta Syndrome due to PIK3CD and PIK3R1 genetic variants) including recently licensed targeted treatment for the latter using a PI3Kinsae inhibitor, leniolisib. Dr.Charlotte Cunnigham Rundles will discuss the impact of genetic disorders presenting as CVID (Common Variable Immune Deficiency) affecting multiple organs due to variants in transcription factors, check point inhibitors, chemokines and cytokines. CVID is one of the most common inborn errors of immunity presenting with infections due to insufficient levels of immune globulins and loss of specific antibodies. However, a significant proportion of these patients develop autoimmune multilineage cytopenias and increased susceptibility to malignancies including lymphoma. These conditions may often be the initial manifestation of the underlying immune defect in a patient who has not had significant infections, and these episodes may recur over time. Treatment of the hematologic complications may require frequent and episodic use of corticosteroids, and/or rituximab; splenectomy is discouraged. Genetic associations noted in CVID patients include CTLA4, LRBA, IKZF1, NFKB1 and NFKB2,STAT3 and STAT1 variants that might provide opportunities for targeted therapeutics. Dr.Thierry Lamy will highlight the impact of clonal evolution of T and Nk cells in LGL (large granular lymphocytosis).Large granular lymphocyte (LGL) leukemia is a rare T/NK cell driven chronic lymphoproliferative disease characterized by neutropenia, anemia and autoimmune disorders such as rheumatoid arthritis, Sjogren syndrome, vasculitis, and autoimmune endocrinopathies. Recent advances in the pathogenesis of LGL leukemia have highlighted the implication of STAT3 genetic variants playing a pivotal role in the leukemic cell proliferation and survival, and autoimmunity. The genetic landscape of LGL is afflicted with gene mutations affecting NF-KB pathway (TNFAIP3), epigenome (TET2, KMT2D), and microenvironment (CCL22). Immunosuppressive agents (cyclophosphamide, methotrexate and cyclosporine) constitute the foundation of first line therapy. Recent advances have led to the development of targeted approaches, including JAK-STAT inhibitors, cytokine targeting and hypomethylating agents, opening novel approaches in an otherwise incurable disease.
Chair:
V. KonetiRao,MD
National Institutes of Health
Bethesda,
MD
Speakers:
V. KonetiRao,MD
NIH
Bethesda,
MD
Beyond FAScinating: Advances in Diagnosis and Management of Autoimmune Lymphoproliferative Syndrome (ALPS)
CharlotteCunningham-Rundles,MD, PhD
Mount Sinai School of Medicine
New York,
NY
Common Variable Immunodeficiency (CVID): Hematologic Presentation and Advances in Molecular Diagnosis
ThierryLamy,MD, PhD
Pontchaillou Hospital Rennes UNIVERSITY HOSPITAL
Rennes,
France
Large Granular Lymphocytosis (LGL): A Clonal Disorder with Autoimmune Manifestations
Follicular Lymphoma: Playing the Long Game
The prolonged survival for most patients with newly diagnosed follicular lymphoma in 2024 is a triumph of the introduction of rituximab a quarter of a century ago. Our improved understanding of follicular lymphoma biology, the heterogeneity of both disease and patients, and new therapeutic options help us in “choosing wisely” the sequencing of treatment for a given patient. We can now be confident of a median 10 years between first and second treatments along with an age-matched survival for patients in sustained remission after immunochemotherapy. In this session, we map the remaining challenges of identifying the minority of patients with early progression and a poor prognosis, as well as the sequencing of the highly promising T-cell immunotherapies for patients with early or multiply-relapsed disease.
In this talk, Dr. Trotman will provide the survival data to equip clinicians in framing optimistic initial conversations with most patients at diagnosis of advanced stage FL. She outlines the expectations of longevity and a “functional cure” for many. She will address considerations of both patient and FL heterogeneity when discussing initial therapy of high tumor burden disease. She provides the data to assist patients who have achieved complete metabolic remission with prognostication and life planning after initial immunochemotherapy.
In this talk, Dr. Casulo will review the origins of POD24 and its impact on survival outcomes in follicular lymphoma. She will review currently available biomarkers and risk calculators for POD24, providing updates on the pathobiology influencing follicular lymphoma prognosis and implicated in POD24. This talk will also explore the impact of histologic transformation on survival in POD24 and outline future directions for management of POD24 in the current era.
Dr. Bartlett will discuss the activity and safety of anti-CD3xCD20 bispecific antibody T-cell engagers and anti-CD19 autologous chimeric antigen receptor T-cells for relapsed or refractory follicular lymphoma. She will review the pivotal clinical trial data, highlighting depth and durations of responses as well as toxicities including cytokine release syndrome, infections, and neurologic events. She will describe a framework for sequencing these classes of agents, additionally taking into account patient factors and logistical considerations.
Chair:
JudithTrotman,FRACP
Concord Repatriation General Hospital
Concord,
NSW,Australia
Speakers:
JudithTrotman,FRACP
Concord Repatriation General Hospital
Concord,
NSW,Australia
Follicular Lymphoma: In Pursuit of a Functional Cure
CarlaCasulo,MD
James P. Wilmot Cancer Center
Rochester,
NY
The POD24 Challenge: Where Do We Go From Here in Follicular Lymphoma?
Nancy L.Bartlett,MD
Washington University School of Medicine
Saint Louis,
MO
Sequencing Bispecific Antibodies and CAR T-cells for FL
It's a Different World: CLL 2024
The treatment of CLL has significantly advanced over the past decade with the introduction of novel targeted therapies. Inhibitors of Bruton’s tyrosine kinase (BTK) as well as BCL2 have supplanted chemoimmunotherapy in both frontline and relapsed therapy. However, while outcomes have improved in the current era, the disease is not cured, and questions still remain about optimal therapies for frontline and relapsed disease. This education session will focus on unanswered questions in CLL, and how current and upcoming research can answer these questions and continue to move the field forward. Dr Stephan Stilgenbauer will discuss risk stratification in CLL and how genomic features influence treatment choice in the frontline setting. He will discuss the implications of genomic risk on outcomes with currently available therapies. Dr Jennifer Woyach will discuss the evidence surrounding doublets and triplets in the frontline treatment of CLL. She will discuss scenarios in which doublets or triplets might be preferred over other standard options, and current and future trials that will help elucidate the use of these treatment for patients. Dr Arnon Kater will discuss the role of immunotherapies in relapsed/refractory CLL. He will discuss the current evidence surrounding transplant, as well as newer paradigms including cellular therapies and bispecific antibodies.
Chair:
Jennifer A.Woyach,MD
The Ohio State University
Columbus,
OH
Speakers:
StephanStilgenbauer,MD
University of Ulm
Ulm,
Germany
Risk-Stratification in Frontline CLL Therapy
Jennifer A.Woyach,MD
The Ohio State University
Columbus,
OH
The Evolving Frontline Management of CLL: Are Triplets Better Than Doublets? How Will We Find Out?
Arnon P.Kater,MD,PhD
Amsterdam UMC
Amsterdam,
Netherlands
Relapsed Refractory CLL: The Role of SCT, Cellular and Non-cellular Immunotherapy
Moving the Needle in Hodgkin Lymphoma
After decades of small incremental shifts in the management of classic Hodgkin lymphoma (cHL), recent studies have accelerated the pace of change in the treatment of cHL. While brentuximab vedotin (BV) has become a standard part of initial treatment for advanced stage disease, studies using PD-1 blockade in the frontline setting are leading to a re-examination of the role of these novel agents for the treatment of cHL. Meanwhile, the novel agents have led to improved outcomes for patients with relapsed/refractory cHL, leading to questions about the timing and role of stem cell transplantation and whether novel therapies alone can lead to durable remission. Dr. Lynch will address whether recent studies using PD1 blockade in frontline treatment of cHL have established a new standard of care for cHL. Dr. Advani will examine the role of BV in the initial treatment of cHL as well as for relapsed/refractory cHL in light of the recent studies in the frontline and salvage setting. Dr. Perales will discuss the evolving role of stem cell transplantation for cHL, optimal salvage regimens, timing and patient selection.
Chair:
Alex F.Herrera,MD
City of Hope
Duarte,
CA
Speakers:
Ryan C.Lynch,MD
Fred Hutchinson Cancer Research Center
Seattle,
WA
Has PD1 Blockade Changed the Standard of Care for cHL?
Ranjana H.Advani,MD
Stanford University
Stanford,
CA
When Should We Use It? The Role of Brentuximab Vedotin in 2024
Miguel AngelPerales,MD
Memorial Sloan Kettering Cancer Center
New York,
NY
When to Use Stem Cell Transplantation for cHL
Newly Diagnosed Multiple Myeloma: Many Choices and More Questions
The treatment of newly diagnosed myeloma has evolved rapidly with the new therapies and different combinations of these, resulting in deeper and more durable responses. The use of autologous stem cell transplantation has also evolved with this progress, and increasingly the initial treatment is being determined agnostic of the transplant eligibility and or desirability. In the decision making process, two factors play an important role, namely the underlying disease risk and the patient functional status or frailty. In particular, increasing disase risk calls for more intense treatments with the goal of achieving MRD negativity while frailty often limits the intensity of the combinations. Phase 3 trials continue to explore the role of quadruplet regimes in older patient populations with increasing depth of response and durable responses, and the nature of the combinations will evolve in the coming years with new classes of drugs being introduced, especially immunotherapies.
Autologous stem cell transplant has been an integral part of myeloma therapy for the past three decades. Originally envisaged as consolidation following initial treatment of newly diagnosed MM in those eligible to undergo the procedure, its role has evolved over time with investigations exploring various aspects including the types of conditioning regimens, role of post-transplant maintenance as well as tandem autologous stem cell transplantation. While the original phase 3 trials compared ASCT with no ASCT and demonstrated improved overall survival, subsequent trials studied the paradigm of delayed ASCT at the time of first relapse, demonstrating significant improvement in PFS but no OS advantage. As the initial therapies for treatment of myeloma has improved with high rate of deep responses, the role of ACT have continued ot be debated, but have maintained its position in the treatment with most recent trials continuing to show an improvement in PFS compared with no ASCT. Dr. Perrot's talk will focus on how ASCT is positioned in the treatment paradigm of MM.
The overall survival in patients with MM over recent decades. This trend is anticipated to further advance with the emergence of T-cell redirecting therapies, including chimeric antigen receptor T-cell (CAR-T) therapy and T-cell engaging bispecific antibodies. Despite these therapeutic advancements, treatment-related adverse events likely impede quality of life. This underscores the imperative of optimizing supportive care strategies to maximize treatment outcomes. Such optimization is crucial not only for patient well-being but also for treatment adherence to sustain long-term disease control. Dr. Zweegmen will discuss treatment and prevention of bone disease, state of the art thrombosis prophylaxis and supportive care during T-cell redirecting therapies targeting BCMA and GPRC5d, amongst which prevention of infections.
Chair:
ShajiKumar,MD
Mayo Clinic
Rochester,
MN
Speakers:
ShajiKumar,MD
Mayo Clinic
Rochester,
MN
What Is the Ideal Approach – Doublet, Triplet or Quadruplet(s)?
AurorePerrot,MD, PhD
CHU de Toulouse, IUCT-O, Université de Toulouse, UPS, Service d’Hématologie
Toulouse,
France
Transplant in Myeloma: Who, When, and Why?
SonjaZweegman,MD, PhD
Amsterdam University Medical Center, Vrije Universiteit Amsterdam
Amsterdam,
Netherlands
Supportive Care in Myeloma – When Treating the Clone Alone Is Not Enough
Not All Lymphadenopathy is Lymphoma: Lymphoproliferative Diseases of Immune Dysregulation
Immune dysregulation often causes lymphadenopathy that requires clinicopathological correlation for accurate diagnosis. This session will review important causes of lymphadenopathy that fall outside the typical spectrum of malignant lymphoma. Castleman disease, IgG4-Related disease and the relationship between EBV and Post-transplant Lymphoproliferative Disorder will be reviewed. A common theme among these sessions is the importance of combining clinical, laboratory, and pathological “clues” to arrive at the best possible diagnosis and management plan.
Dr. Fajgenbaum will provide an overview on the classification, diagnosis, and management of Castleman disease. Castleman disease is a heterogeneous group of lymphoproliferative disorders, and idiopathic multicentric Castleman disease (iMCD) can be particularly difficult to diagnose and distinguish from other inflammatory causes of lymphadenopathy. Diagnostic criteria for iMCD and the subtypes of iMCD including thrombocytopenia, anasarca, (reticulin) fibrosis, renal dysfunction and organomegaly (iMCD-TAFRO), idiopathic plasmacytic lymphadenopathy (iMCD-IPL) and not otherwise specified (iMCD-NOS) will be reviewed.
Dr. Chen will review IgG4-related disease (IgG4-RD), a disease of immune dysregulation with protean manifestations including autoimmune pancreatitis, sclerosing cholangitis, lacrimal and salivary gland swelling, and tubulointerstitial nephritis. The session will focus on an approach to four key manifestations for Hematologists: Polyclonal hypergammaglobulinemia, IgG4-positive plasma cell enriched lymphadenopathy, eosinophilia, and retroperitoneal fibrosis. Practical tips for differentiating IgG4-RD from key mimickers such as Castleman disease, eosinophilic vasculitis, and histiocyte disorders will be highlighted.
Dr. Rouce will discuss the interplay between Epstein-Barr virus (EBV) and Post-tranplant lymphoproliferative disorder (PTLD). The spectrum of PTLD includes three variations of lymphoproliferation: lymphoid hyperplasia, neoplasia and malignancy. Lymphoid hyperplasia is characterized by polyclonal proliferation and non-destructive lesions whereas lymphoid malignancy features monoclonal proliferation and destructive lesions. EBV is the main driver of PTLD, and management ranges from reduction in immunosuppression to intensive, lymphoma-directed therapy.
Chair:
Luke Y. C.Chen,MD,MEd
Dalhousie University
Halifax,
NS,Canada
Speakers:
David C.Fajgenbaum,MD, MBA, MSc
University of Pennsylvania
Philadelphia,
PA
Identifying Castleman Disease from Non-Clonal Inflammatory Causes of Generalized Lymphadenopathy
Luke Y. C.Chen,MD,MEd
Dalhousie University
Halifax,
NS,Canada
IgG-4 Disease for the Hematologist
RayneRouce,MD
Texas Children's Hospital
Houston,
TX
EBV and Post-transplant Lymphoproliferative Disorder (PTLD): A Complex Relationship
ѻý Spotlight Sessions
Smoldering Myeloma: A Case for Early Intervention?
Smoldering Multiple Myeloma (SMM) is a precursor plasma cell disorder characterized by the presence of an M-component concentration equal to or greater than 3 g/dL and/or bone marrow plasma cell infiltration of 10-59%, without any myeloma-defining events. The outcome is heterogeneous, especially regarding progression to active disease such as Multiple Myeloma or other plasma-cell related disorders. The current standard of care is observation, but ongoing and completed research suggests it is possible and straightforward to identify SMM patients at high risk of progression to Multiple Myeloma (50% at 2 years).
This session will feature two clinical cases that highlight the issues involved in determining whether early treatment is the optimal approach for managing this precursor plasma cell disorder and if early treatment is the only way to potentially cure Multiple Myeloma.
Dr. Mateos will discuss the role of early treatment in Smoldering Myeloma as a strategy to cure the disease. She will present evidence supporting the benefits of early intervention and its impact on long-term outcomes.
Dr. Ramasamy will provide a counterpoint to this approach, addressing the costs and toxicities associated with early treatment. He will discuss the potential downsides and argue for a more conservative management approach based on observation.
We look forward to a dynamic and educational session that will provide valuable insights into the management of Smoldering Multiple Myeloma
Chair:
Maria-VictoriaMateos,MD, PhD
University Hospital of Salamanca/IBSAL/Cancer Research Center-IBMCC (USAL-CSIC)
Salamanca,
Spain
Speakers:
Maria-VictoriaMateos,MD, PhD
University Hospital of Salamanca
Salamanca,
Spain
Point: Yes, That is the Only Way We Can Cure Myeloma?
KarthikRamasamy,MD,PhD
University of Oxford
Oxford,
United Kingdom
Counterpoint: No, It Just Adds Cost and Toxicity?
Scientific Program
Host Factors Driving Anti-Leukemia Immunotherapy Outcomes
Scientific Committee on Immunology and Host Defense
This session will cover how the immune microenvironment of the host interacts with leukemia cells and how the donor immune system can exert graft-versus-leukemia (GVL) effects. The speakers will focus on the characterization of immune effector cells and leukemia cells using high resolution RNA and protein analysis, the characterization of metabolites that impact the GVL effect and kinase inhibition strategies to overcome immune escape mechanisms of leukemia cells.
Dr. Catherine Wu will discuss the components critical to devising effective immunotherapy for the treatment of myeloid leukemia, namely the identification of myeloid malignancy antigen targets, and the detection of critical immune cell effectors. The analysis of GvL responses following allogeneic stem cell transplant for AML/MDS, through single cell transcriptome and spatial analysis of marrow specimens, is a particularly instructive setting from which to detect key antigens and cell subpopulations implicated in anti-leukemia responses. The insights gained from the study of such GVL settings promise to provide a roadmap for devising new immunotherapeutic approaches for myeloid malignancies.
Dr. Takanori Teshima will discuss mechanisms of leukemia relapse after allogeneic hematopoietic stem cell transplantation and novel strategies to prevent relapse by inhibiting immune escape of leukemic cells, restoring immune cell dysfunction, and turning “COLD” into “HOT” immune microenvironment. In addition, novel strategies to separate GVL from GVHD by controlling migration and activation of donor T cells in the vicinity of leukemic cells.
Chair:
RobertZeiser,MD
ԾäٲԾܳ Freiburg
Freiburg,
Germany
Speakers:
Catherine J.Wu,MD
Harvard Medical School
Boston,
MA
Immune Microenvironment and GVL Effects
TakanoriTeshima,MD,PhD
Hokkaido University
Sapporo,
Hokkaido,Japan
Firing Up COLD Tumor Microenvironment to Facilitate GVL
FranziskaBlaeschke,MD,PhD
German Cancer Research Center (DKFZ)
Heidelberg,
Germany
Immune Metabolism in T Cells Acting Against Leukemia Cells
JOINT SESSION: Molecular Characterization of Lymphomas in Children, Adolescents, and Young Adults
Scientific Committee on Blood Disorders in Childhood + Scientific Committee on Lymphoid Neoplasia
Dynamic advances in the molecular characterization of lymphomas continue to shape how these malignancies are classified and inform therapeutic targeting. This joint session will provide a state-of-the-science update on next-generation technologies used to explore that special group of lymphoma subtypes that are most prevalent in pediatric, adolescents, and young adults. The speakers represent experts in these methods and will highlight exciting applications in elucidating lymphoma biology (especially age-related differences in pathogenesis), including enhancing clinical management.
Dr. Lisa Roth will discuss ongoing efforts to delineate the genomic landscape of classic Hodgkin lymphoma (cHL). Historically, genetic evaluation of cHL has been limited by the scarcity of Hodgkin and Reed-Sternberg (HRS) cells in cHL tumors. This has been overcome in recent years using fluorescence-activated cell sorting to isolate HRS cells from cHL tissues and evaluation of circulating tumor DNA, which have revealed tumors with high mutational burden, complex structural variants, and genomic subtypes with distinct clinical and molecular characteristics. The applicability of these findings to develop prognostic biomarkers and novel therapeutics will be discussed.
Dr. Tomohiro Aokiwill discuss emerging single-cell technologies that have enabled better understanding of the comprehensive interactions within the cHL tumor microenvironment at an unprecedented resolution. Considering current pathogenesis models where HRS cells “recruit and re-educate” their microenvironment to create an immuno-suppressive milieu, cHL has emerged as one of the most exciting fields for application of these cutting-edge technologies. Dr. Aoki will summarize new insights gained using CyTOF, single-cell RNA sequencing and multiplexed imaging techniques, and discuss potential implications for clinical decisions.
Dr. Birgit Burkhardtwill provide a comprehensive update of recurrent genetic variants reported in Burkitt lymphoma (BL) in several recent studies. Covering both endemic and sporadic BL, Dr. Burkhardt will highlight the impact of patient age at diagnosis on molecular characteristics and its implications for pathogenesis. Incorporation of specific variants as potential biomarkers for risk group stratification in upcoming BL clinical trials will also be discussed.
Dr. Björn Chapuywill discuss novel (epi)genomic analyses employed to define molecular heterogeneity in B-cell lymphoma subtypes and identify clinically actionable alterations, with a focus on primary mediastinal large B-cell lymphomas (PBMLs). With biometric features that often overlap with cHL, PMBLs are distinguished by their typical manifestation in young female patients and sensitivity to PD-1 blockade. Dr. Chapuy will present evolving approaches to comprehensive genetic analysis used to inform and test response to therapies that target such mechanisms of immune escape.
CoChair:
Speakers:
Lisa GiulinoRoth,MD
Weill Cornell Medicine
New York,
NY
Genomic Landscape in Hodgkin Lymphoma
TomohiroAoki,MD, PhD
Princess Margaret Cancer Center
Toronto,
ON,Canada
Sequencing Technologies in Hodgkin Lymphoma
BirgitBurkhardt,MD,PhD
University Hospital Münster
Muenster,
Germany
Age-Related Molecular Changes in Burkitt Lymphoma
BjörnChapuy
Charité - University Medical Center Berlin, Campus Benjamin Franklin
Berlin,
Germany
Functional Genomics of Non-Hodgkin Lymphoma in Children, Adolescents, and Young Adults
Metabolic Deregulation in Hematopoietic Neoplasia: Tumor, The Environment, and Therapies.
Scientific Committee on Hematopathology and Clinical Laboratory Hematology
Cellular metabolism and its role in the pathogenesis of hematologic malignancies is an emerging area of research. Recent studies implicate various cellular mechanisms by which oncogenic activation of metabolic pathways contribute to lymphoid and myeloid malignancies as well as their respective tumor environment. In this session, the speakers will discuss the role of deregulated cellular metabolism that contributes to lymphoid and myeloid malignancies and how they may provide novel insights with therapeutic relevance. The metabolic control of T cell differentiation and their function in immunity will also be discussed. This session highlights the opportunities for gaining novel mechanistic insights of hematologic malignancies through global metabolomic studies that has potential to impact the field of T-cell immunology, immunotherapies and facilitate translation to clinical practice.
Chair:
Megan S. SLim,MD,PhD
Memorial Sloan Kettering Cancer Center
New York City,
NY
Speakers:
Jürgen MaximilianRuland
Technical University of Munich
Munich,
Germany
Novel Insights in Metabolic Deregulation in Lymphoid Malignancies
PaoloGallipoli,MD
Queen Mary University of London
London,
United Kingdom
Targeting Metabolic Deregulation in Acute Myeloid Leukemia
AnandaGoldrath,PhD
Allen Institute
Seattle,
WA
Metabolic Control of T Cell Differentiation and Function in Tumor Immunity
Proteo-Genomics to Better Study Multiple Myeloma Biology and Evolution
Scientific Committee on Plasma Cell Neoplasia
Cancer proteogenomics provides new biological and diagnostic knowledge that can improve our understanding of malignant transformation and therapeutic outcomes. This area is new in plasma cell neoplasia. In this session the speakers will discuss how proteogenomics can lead to a better study of multiple myeloma (MM) biology and support the development of novel therapeutic targets in MM.
Dr. Jan Krönke will discuss the impact of proteogenomic studies on our understanding of MM biology. He will outline how proteomics improve risk stratification, and reveal deregulated proteins and pathways that can be exploited for new therapies in MM.
Dr. Francesco Maura will present the genomic landscape of MM and its precursor conditions, with a particular focus on the temporal acquisition of various combinations of genomic drivers. He will highlight the relevance of these genomic patterns in predicting MM progression and identifying the most effective immunotherapy for MM patients.
Dr. Fabiana Perna will describe a strategy for probing the MM surface proteome (surfaceome) with mass-spectrometry and transcriptomic analyses to identify novel immunotherapeutic targets. She will discuss the contribution that the surfaceome makes to MM biology as well as the pre-clinical development of novel chimeric antigen receptor platforms for MM.
Chair:
PaolaNeri,MD,PhD
Arnie Charbonneau Cancer Institute, University of Calgary
Calgary,
AB,Canada
Speakers:
JanKronke,MD
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health
Berlin,
Germany
Defining the Proteomic Landscape of Multiple Myeloma
FrancescoMaura,MD
University of Miami
Palmetto Bay,
FL
Genomic Drivers Involved in Myeloma Progression and Development of Resistance
FabianaPerna,MD, PhD
H. Lee Moffitt Cancer Center and Research Institute
Tampa,
FL
Proteo-Genomics to Better Study Cell Surfaceome in Multiple Myeloma
Scientific Spotlight Sessions
Biology Underlying Disparities in Lymphoid Malignancies
Significant disparities in outcomes have been described for several lymphoma subtypes, most notably related to race and HIV status. Although socioeconomic factors often play a role, new approaches are needed to determine whether distinct pathogenic mechanisms underlie such disparities. The modern era has been marked by major advances in understanding lymphoma pathobiology, but populations affected by disparities are woefully under-represented in most of these pivotal studies. This session will highlight recent, innovative work dedicated to closing this knowledge gap and identifying molecular targets for improving outcomes in vulnerable populations.
CoChair:
Speakers:
Christopher R.Flowers,MD, MS
The University of Texas MD Anderson Cancer Center
Houston,
TX
Tumor Sequencing to Investigate Disparities in Lymphoma
WendyCozen,DO, MPH
UCI, School of Medicine
Orange,
CA
Tumor Microenvironment Profiling to Investigate Disparities in Hodgkin Lymphoma and Multiple Myeloma
Special-Interest Sessions
ASH Clinical Practice Guidelines on Acute Lymphoblastic Leukemia (ALL) in Adolescents and Young Adults
This session will preview recommendations for initial therapy and management of remission and relapse in adolescents and young adults with ALL.
Chair:
SumitGupta,MD, PhD
Hospital for Sick Children
Toronto,
ON,Canada
Speakers:
JulieWolfson,MD, MSHS
The University of Alabama at Birmingham
Birmingham,
AL
Management of Frontline ALL in AYA
Jennifer L.McNeer,MD
University of Chicago
Chicago,
IL
Management of Frontline ALL in AYA
Kristen M.O'Dwyer,MD
University of Rochester
Rochester,
NY
Management of Refractory and Relapse of ALL in Adolescents and Young Adults
Lena EWinestone,MD
University of California San Francisco
San Francisco,
CA
Management of Refractory and Relapse of ALL in Adolescents and Young Adults
ASH Clinical Practice Guidelines on Amyloidosis
This session will review the scope and goals of the upcoming guidelines on amyloidosis, and will provide insights on risk factors, selecting a target site versus a surrogate site for diagnostic biopsies, and using Congo Red stain screening.
Chair:
վܰپ
University Health Network
Toronto,
ON,Canada
Speakers:
AngelaDispenzieri,MD
Mayo Clinic
Rochester,
MN
Target Site vs. Surrogate Site Biopsy for Diagnosis
JoselleCook,MBBS
Mayo
Rochester,
MN
Increasing Awareness of Risk Factors for AL Amyloidosis
NareshBumma,MD
The Ohio State University
Columbus,
OH
Congo Red Stain Screening for AL Amyloidosis
HiraShaikh,MD
University of Iowa Caver College of Medicine
Coralville,
IA
Target Site Vs. Surrogate Site Biopsy for Diagnosis
ASH Research Collaborative Multiple Myeloma Network: Accelerating Research and Collaborative Clinical Care through Real-World Evidence Generation
This 90-minute special-interest session will focus on the ASH Research Collaborative’s Multiple Myeloma Program’s efforts to accelerate research and collaborative clinical care in hematologic malignancies. Three topics will describe the ASH Research Collaborative’s approach to aggregating and visualizing real-world data (RWD) in multiple myeloma in a US-based, multi-site network; a proof-of-concept study with a hybrid decentralized workflow that was conducted in the ASH RC Myeloma Network this year; and new directions for RWD analysis in hematologic malignancies, including the use of artificial intelligence. A panel will then highlight work that is being done by the European HARMONY Alliance and other real-world data registries.
Chair:
Kenneth C.Anderson,MD
Dana-Farber Cancer Institute
Boston,
MA
Speakers:
William A.Wood,MD,MPH
University of North Carolina At Chapel Hill Hospital
Chapel Hill,
NC
Building a National Multiple Myeloma Data Hub to Accelerate Research and Enhance Clinical Care
Saad Z.Usmani,MD
Memorial Sloan Kettering Cancer Center
New York,
NY
Working with Data Hub Data and Network PIs to Develop Evidence that Changes Practice in Multiple Myeloma: The COSMIC Study as Proof of Concept
ShajiKumar,MD
Mayo Clinic
Rochester,
MN
Pushing Data Frontiers: How Artificial Intelligence and Molecular Data can Facilitate Translational Research in the Network
Jesus MariaHernandez Rivas,MD
University of Salamanca, IBSAL, IBMCC, CSIC
Salamanca,
Spain
Panel Discussion: Real World Experience with Establishing Registries and Reporting Results (Panelist 1)
ElenaZamagni,MD
Bologna University School of Medicine
Bologna,
Italy
Panel Discussion: Real World Experience with Establishing Registries and Reporting Results (Panelist 2)
Doris K.Hansen,MD
H. Lee Moffitt Cancer Center and Research Institute
Tampa,
FL
Panel Discussion: Real World Experience with Establishing Registries and Reporting Results (Panelist 3)
Symposium on Quality: Treating Fairly - The Role of Quality Improvement in Combating Health Care Disparities
This year's Quality Symposium will focus on practical strategies for combatting healthcare disparities. First, Dr. Melissa Creary will discuss the Michigan Social Health Interventions to Eliminate Disparities (MSHIELD) program, a statewide data-driven, community-partnered, and equity-centered quality improvement effort. Then Dr. Michelle Sholzberg will review the development and impact of the "Raise the Bar" project, which aims to eliminate disparities in the recognition and management of iron deficiency by adjusting reference ranges. The session will conclude with a talk by Dr. Thomas Greg Knight on mitigating the impact of financial toxicity in patients with hematologic malignancies.
CoChair:
Speakers:
MelissaCreary
University of Michigan School of Public Health
Ann Arbor,
MI
MSHIELD - Michigan Social Health Interventions to Eliminate Disparities
MichelleSholzberg,MDCM, MSc
University of Toronto
Toronto,
ON,Canada
Raise the Bar - Combatting Disparities in the Recognition and Management of Iron Deficiency
Thomas G.Knight,MD
Atrium Health
Charlotte,
NC
Cancer and Poverty - Mitigating the Impact of Financial Toxicity in Patients with Hematologic Malignancies
Trainee Activities and Services
Blood Buddies: Adult Clinical Malignant Hematology
Trainees have the opportunity to meet with leaders in the field. Trainees sign up for a one-on-one Blood Buddy ten-minute mentoring session with a faculty member. Blood Buddies are experts in various hematology topic areas. This is an excellent opportunity for trainees to network with and receive mentorship from seasoned faculty. There are 3 Blood Buddies sessions at the event. Although the speakers roles are marked as primary and alternate, multiple speakers may be asked to present on the same topic if that topic will be repeated in the following sets of Blood Buddies. The featured topics are: Adult Clinical Malignant Hematology; Pediatric Clinical Malignant Hematology; Adult Clinical Classical Hematology; Pediatric Clinical Classical Hematology; BMT Pediatric and Adult; Quality Improvement; Medical ѻý; PhD/Laboratory; Diversity, Equity, and Inclusion; International Medical Graduates; Future of Hematology (Artificial Intelligence); Industry Career Pathway; Federal Career Pathway.
Career Development Lunch
This session provides an intimate venue for trainees to meet with leaders in hematology to discuss careers in the wide array of practice areas within hematology, including basic, clinical, and translational research, PhD careers, careers in industry settings, and careers in private and clinical practice. There will are multiple tables dedicated to each career area and one faculty member at each table leading the discussion. A boxed lunch is provided. This is a first come, first served event that is usually very-well attended. The full list of topics covered are: Adult BMT; Pediatric BMT; Adult Clinical Malignant Hematology; Adult Clinical Classical Hematology; Clinical Careers in Hematology (Private Practice Careers); Government Careers (NIH and FDA); Industry Careers; Laboratory and Translational Hematology; Medical Educators in Hematology; Pediatric Clinical Hematology; PhD careers; Systems-Based Hematology; Global Hematology; Maternal Health; Medical Informatics and AI; Lifespan; and Geriatric Hematology.
Chair:
Բܳ
Moffitt Cancer Center
Lutz,
FL
Yvonne A.Efebera,MD
Ohio Health
Columbus,
OH
Rakhi P.Naik
,MD
Johns Hopkins Hospital
Baltimore,
MD
Hematology-Focused Fellowship Training Program (HFFTP)
Dzٱ
Dana-Farber Cancer Institute, Inc.
Boston,
MA
Hematology-Focused Fellowship Training Program (HFFTP)
PallawiTorka
,MD
Roswell Park Comprehensive Cancer Center
Buffalo,
NY
International Graduate Hematology
ShrutiChaturvedi
,MBBS
Johns Hopkins University School of Medicine
Baltimore,
MD
International Graduate Hematology
ղԲⲹ¾
University of Nebraska
Omaha,
NE
Geriatric Hematology
Alexander ABoucher
,MD
University of Minnesota
Minneapolis,
MN
Lifespan Hematology
Matthew J.Maurer
,DSc
Mayo University
Rochester,
MN
Medical Informatics and AI
ܱԲ
University of Ulm
Berlin,
Germany
Medical Informatics & AI
PaulaJames
,MD, FRCPC
Queen's University
Kingston,
ON,Canada
Maternal Health
AliBazarbachi
,MD, PhD
American University of Beirut Medical Center
Beirut,
Lebanon
International Opportunities Hematology
KoheiHosokawa
,MD, PhD
Kanazawa University
Kanazawa,
Japan
International Opportunities Hematology
վܰپ
University Health Network
Toronto,
ON,Canada
Systems Based Hematology
ShannonElf
,PhD
The University of Chicago
Chicago,
IL
PhD Careers
ParvathiRanganathan
,PHD
Ohio State University
Columbus,
OH
PhD Careers
SaraVesely
,PhD
The Univ. of OK Health Sciences Ctr.
Oklahoma City,
OK
Pediatric Clinical Hematology
Angela CWeyand
,MD
University of Michigan Medical School
Ann Arbor,
MI
Pediatric Clinical Hematology
AndrewVolk
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Laboratory and Translational Hematology
SanjayMohan
,MD
Vanderbilt University Medical Center
Nashville,
TN
Medical Educators in Hematology
Tapan M.Kadia
,MD
MD Anderson Cancer Center
Houston,
TX
Medical Educators in Hematology
ٲԾմǷɲԲ
Astra Zeneca
Potomac,
MD
Industry Careers
E. Leila JeromeClay
,MD
Johns Hopkins
Watertown,
MA
Industry Careers
Julie A.Panepinto
,MD, MSPH
Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute
Bethesda,
MD
Government Careers (NIH and FDA)
CaraRabik
,MD,PhD
Food and Drug Administration
Silver Spring,
MD
Government Careers (NIH and FDA)
Adrienne MHammill
,MD, PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
ܱ
Columbus Oncology and Hematology
Columbus,
OH
Private Practice Hematology
MariaCarter Febres
,MD
Cincinnati Children's Hospital
Cincinnati,
OH
Pediatric Hematology
Alfred ILee
,MD, PhD
Yale University School of Medicine
New Haven,
CT
Adult Classical Hematology
PayalDesai
,MD
Wake Forest University
Charlotte,
NC
Adult Classical Hematology
HannyAl-Samkari
,MD
Massachusetts General Hospital, Harvard Medical School
Boston,
MA
Adult Classical Hematology
SumithiraVasu
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult Malignant Hematology
BasemWilliam
,MD
OhioHealth Marion General Hospital
Columbus,
OH
Adult Malignant Hematology
²
Ohio State University Medical Center
Columbus,
OH
Adult Malignant Hematology
Nirali N.Shah
,MD
NIH
Bethesda,
MD
Pediatric BMT/CAR-T
RayneRouce
,MD
Texas Children's Hospital
Houston,
TX
Pediatric BMT/CAR-T
Abdullah MohammadKhan
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult BMT/Cellular Therapy
NareshBumma
,MD
The Ohio State University Comprehensive Cancer Center
COLUMBUS,
OH
Adult BMT/Cellular Therapy
Monique A.Hartley-Brown
,MD
DFCI
Boston,
MA
Adult BMT/Cellular Therapy
Ჹ
MD Anderson Medical Center
Loma Linda,
TX
Pediatric BMT/CAR-T
Mikkael A.Sekeres
,MD
University of Miami Miller School of Medicine
Miami,
FL
Adult Malignant Hematology
OyebimpeAdesina
,MD,MS
UC Davis Comprehensive Cancer Center
Sacramento,
CA
Adult Classical Hematology
YiZheng
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
StevenFein
,MD,MPH
University of Miami
Miami,
FL
Private Practice Hematology
Elaine S.Jaffe
,MD
National Cancer Institute, National Institute of Health
Bethesda,
MD
Government Careers (NIH and FDA)
Ѳܻ
Bristol Myers Squibb
Madison,
NJ
Industry Careers
Alisa SWolberg
,PhD
University of North Carolina at Chapel Hill
Chapel Hill,
NC
Laboratory and Translational Hematology
ԻⲹʲԳ
National Institutes of Health
Seattle,
WA
Medical Educators in Hematology
Sarah H.O'Brien
,MD,MSc
Ohio State University
Columbus,
OH
Pediatric Clinical Hematology
MargaretGoodell
,PhD
Center for Cell and Gene Therapy, Baylor College of Medicine
Houston,
TX
PhD Careers
ǰʲ
University of California
Oakland,
CA
Systems Based Hematology
dz
Baskent University
Ankara,
Turkey
International Opportunities Hematology
LisaBaumann Kreuziger
,MD, MS
Versiti
Milwaukee,
WI
Maternal Health
James S.Blachly
,MD
The Ohio State University
Columbus,
OH
Medical Informatics & AI
RebeccaKruse-Jarres
,MD,MPH
University of Washington
Seattle,
WA
Lifespan Hematology
AshleyRosko
,MD
The Ohio State University
Columbus,
OH
Geriatric Hematology
첹Գٳ
Baptist Health South Florida
Miami,
FL
International Graduate Hematology
Metabolic Disorders
ѻý Program
Integrating New Therapies into the Management of Classical Heme Disorders
This session will provide an overview on the current evidence of different novel therapies for the management of Classical Heme Disorders including ß-Thalassemia, Acute Intermittent Porphyria?(AIP) and anemia in chronic kidney disease (CKD).
Dr. Volker Haasewill outline mechanisms of action and pharmacologic properties of HIF-prolyl hydroxylase inhibitors (HIF-PHIs), a new class of oral anemia drugs approved for the use in patients with chronic kidney disease (CKD). He willdiscuss nondesirableon-target and off-target effects, cardiovascular and other safety concerns, and provide a benefit/risk-based perspective on how this new class of oral drugs might impact current management of anemia in CKD. A clinical case is presented that highlights the clinical complexities and therapeutic challenges in the management of anemia in patients with CKD.
Prof. Taher will highlight persisting unmet needs in patients with non-transfusion-dependent and transfusion-dependent ß-thalassemia. His presentation will overview the current evidence base for luspatercept as a novel disease-modifying agent targeting ineffective erythropoiesis in ß-thalassemia. He will also provide guidance on best-practices for practical application of luspatercept in the real world setting and identify emerging data gaps.
For Dr. Dickey’s presentation, she will review the givosiran clinical trial data and the available clinical literature on givosiran, as well as highlight important unanswered questions.
Chair:
Ali T.Taher,MD, FRCP
American University of Beirut Medical Center
Beirut,
Lebanon
Speakers:
Volker HansHaase
Vanderbilt University
Nashville,
TN
Hypoxia-Inducible Factor (HIF) Activators: ANovel Class of Oral Drugs for the Treatment of Anemia of Chronic Kidney Disease
Ali T.Taher,MD, FRCP
American University of Beirut Medical Center
Beirut,
Lebanon
Luspatercept: A Treatment for Ineffective Erythropoesis in Thalassemia
پ,Ѷ
Massachusetts General Hospital
Boston,
MA
Givosiran: A Targeted Treatment for Acute Intermittent Porphyria
Ironing Out the Wrinkles: Managing Iron Overload in Different Clinical Scenarios
Iron homeostasis and porphyrin metabolism must be closely coordinated to ensure efficient biosynthesis of heme. Disturbed coordination is exemplified by sideroblastic anemias, which are characterized by insufficient incorporation of iron into the end product of the prophyrin biosynthesis pathway, resulting in anemia and mitochondrial as well as systemic iron overload. Conversely, iron overload from other causes, like hereditary hemochromatosis, can have unfavourable effects on porphyrin synthesis, provoking porphyria cutanea tarda. The intricate interplay between iron and porphyrin metabolism can be disturbed by inherited or acquired causes. Therapeutic options to mitigate the ensuing clinical symptoms are highlighted by the three speakers of this session.
Dr. Domenico Girelli will discuss hereditary hemochromatosis according to the recent clinically oriented classification. While hyperferritinemia is common in practice, hemochromatosis accounts for few cases, typically with increased transferrin saturation. HFE-related hemochromatosis has a low penetrance, influenced by lifestyle and dysmetabolic factors. Most patients are currently identified in the early phases before life-threatening manifestations. Phlebotomy remains the mainstay for achieving iron depletion, with blood donation being an option for maintenance. The management of rare, severe non-HFE forms, requiring a comprehensive approach, will also be presented.
Dr. Norbert Gattermann will outline the pathophysiology of systemic iron overload in MDS as well as mitochondrial iron accumulation in patients with acquired sideroblastic anemias. He will explain how SF3B1 mutations and the subsequent missplicing and deficiency of ABCB7 may lead to impaired heme synthesis and excess mitochondrial iron. The rationale for iron chelation therapy in MDS will be considered, together with some of its practical aspects. Finally, Dr. Gattermann will assess the extent to which luspatercept might contribute to the management of iron overload in patients with MDS.
Dr. Rebecca Leaf will focus on porphyria cutanea tarda (PCT), a disorder of heme biosynthesis that arises due to inhibition of hepatic uroporphyrinogen decarboxylase in the setting of increased liver iron content and oxidative stress. Patients with PCT invariably have siderosis on liver biopsy and up to 20% are homozygous for the HFE C282Y mutation. PCT manifests as blistering cutaneous lesions on sun-exposed areas, skin fragility, and elevated plasma and urine porphyrins. Treatment includes therapeutic phlebotomy to decrease total body iron levels and hydroxychloroquine, which reduces hepatic porphyrin content.
Chair:
NorbertGattermann,MD
Heinrich Heine University Dusseldorf
Dusseldorf,
Germany
Speakers:
DomenicoGirelli,MD,PhD
University of Verona
Verona,
Italy
Diagnosis and Management of Hereditary Hemochromatosis: Lifestyle Modification, Phlebotomy, and Blood Donation
NorbertGattermann,MD
Heinrich Heine University Dusseldorf
Dusseldorf,
Germany
Management of Iron Overload in Acquired Sideroblastic Anemias and MDS: Role of Chelation and Luspatercept
RebeccaLeaf
Mass General Hospital Cancer Center
Boston,
MA
Porphyria Cutanea Tarda: A Unique Iron-Related Disorder
Scientific Program
Crosstalk Between Iron Homeostasis and Metabolism
Scientific Committee on Iron and Heme
Maintaining iron balance is fundamental to preserve metabolic functions and energy requirements. This session reflects the current understanding of the reciprocal relationship existing between iron homeostasis and energetic metabolism. It aims to highlight the regulatory role of heme and iron on glucose and lipid metabolism as well as the impact of metabolism on the modulation of the iron status. Novel findings will be presented about the physiologic and pathologic implications of iron-mediated regulation of metabolism, and metabolite-driven control of iron and heme homeostasis. The session will focus on b-thalassemia, sickle cell disease and obesity, and will have broad relevance to all hematologic and non-hematological diseases.
Dr. Antonella Nai will discuss the role of Transferrin Receptor2 (TFR2) in the reciprocal regulation between iron homeostasis, erythropoiesis, and glucose metabolism. TFR2 is an iron sensor acting as a brake of erythropoietin signaling in erythroid cells. Its genetic inactivation in the hematopoietic compartment enhances erythropoiesis and improves anemia in ß-thalassemia. She will present unpublished data demonstrating that Tfr2 deficiency increases the metabolic activity of erythroid cells, thus promoting glucose consumption and reducing blood glycemia. This is particularly relevant in ß-thalassemia, whereby glucose intolerance and diabetes are common and invalidating complications.
Dr. Wei Ying will focus on the connection between iron homeostasis and lipid metabolism. He will present findings related to the role of iron homeostasis in regulating hepatocyte lipogenesis and neighboring cell responses, including hepatic stellate cells, and describe how alterations of these mechanisms drive non-alcoholic fatty liver disease, steatohepatitis and obesity.
Dr. Leitinger will share how heme triggers a unique bioenergetic switch in macrophages, characterized by a metabolic shift from oxidative phosphorylation towards glucose consumption, and its critical role in the effective clearance and detoxification of heme in sickle cell disease. Based on the previous identification of the phosphofructokinase PFKFB3 as key mediator of the metabolic switching in heme-detoxifying macrophages, he will present data about a potential therapeutic strategy involving the inhibition of PFKFB3 in a mouse model of sickle cell disease. Furthermore, the general clinical relevance of these processes for patients with hemolytic disorders will be discussed.
Chair:
FrancescaVinchi,PhD
New York Blood Center
New York,
NY
Speakers:
AntonellaNai,PhD
IRCCS San Raffaele Scientific Institute
Milan,
Italy
Iron, Erythropoiesis, and Glucose Metabolism
WeiYing,PhD
University of California San Diego
La Jolla,
CA
Iron and Lipid Metabolism
NorbertLeitinger
University of Virginia
Charlottesville,
VA
Heme and Macrophage Metabolism.
JOINT SESSION: Emerging Therapeutic Strategies Targeting Epigenetic, Transcriptomic, and Metabolic Mechanisms
Scientific Committee on Epigenetics and Genomics + Scientific Committee on Myeloid Neoplasia
Recent developments in therapeutic targeting of various mechanisms of epigenetic, transcriptomic, and metabolic vulnerabilities in cancer utilize novel technologies and may provide future breakthroughs. Given the extensive amount of knowledge derived from high throughput methodologies in the last decade, rational targeting is now possible, with sophisticated mechanistic studies to study the effects of targeting. This session will focus on novel research aimed at identifying and targeting these molecules, including novel targeting approaches such as heterobifunctional molecules and others.
CoChair:
Speakers:
Hannah JUckelmann,PhD
Frankfurt Cancer Institute
Frankfurt,
Germany
Novel Inhibitors of Transcriptional Mechanisms
Gerald R.Crabtree,MD
Stanford University
Stanford,
CA
Heterobifunctional Molecules Targeting Epigenetic Mechanisms
BenjaminCravatt,PhD
The Scripps Research Institute
San Diego,
CA
Inhibitors of RNAs and RNA Binding Proteins.
CourtneyJones,PhD
Cincinnati Children's Hospital
Cincinnati,
OH
Targeting Metabolic Vulnerabilities
Special-Interest Sessions
Symposium on Quality: Treating Fairly - The Role of Quality Improvement in Combating Health Care Disparities
This year's Quality Symposium will focus on practical strategies for combatting healthcare disparities. First, Dr. Melissa Creary will discuss the Michigan Social Health Interventions to Eliminate Disparities (MSHIELD) program, a statewide data-driven, community-partnered, and equity-centered quality improvement effort. Then Dr. Michelle Sholzberg will review the development and impact of the "Raise the Bar" project, which aims to eliminate disparities in the recognition and management of iron deficiency by adjusting reference ranges. The session will conclude with a talk by Dr. Thomas Greg Knight on mitigating the impact of financial toxicity in patients with hematologic malignancies.
CoChair:
Speakers:
MelissaCreary
University of Michigan School of Public Health
Ann Arbor,
MI
MSHIELD - Michigan Social Health Interventions to Eliminate Disparities
MichelleSholzberg,MDCM, MSc
University of Toronto
Toronto,
ON,Canada
Raise the Bar - Combatting Disparities in the Recognition and Management of Iron Deficiency
Thomas G.Knight,MD
Atrium Health
Charlotte,
NC
Cancer and Poverty - Mitigating the Impact of Financial Toxicity in Patients with Hematologic Malignancies
Trainee Activities and Services
Career Development Lunch
This session provides an intimate venue for trainees to meet with leaders in hematology to discuss careers in the wide array of practice areas within hematology, including basic, clinical, and translational research, PhD careers, careers in industry settings, and careers in private and clinical practice. There will are multiple tables dedicated to each career area and one faculty member at each table leading the discussion. A boxed lunch is provided. This is a first come, first served event that is usually very-well attended. The full list of topics covered are: Adult BMT; Pediatric BMT; Adult Clinical Malignant Hematology; Adult Clinical Classical Hematology; Clinical Careers in Hematology (Private Practice Careers); Government Careers (NIH and FDA); Industry Careers; Laboratory and Translational Hematology; Medical Educators in Hematology; Pediatric Clinical Hematology; PhD careers; Systems-Based Hematology; Global Hematology; Maternal Health; Medical Informatics and AI; Lifespan; and Geriatric Hematology.
Chair:
Բܳ
Moffitt Cancer Center
Lutz,
FL
Yvonne A.Efebera,MD
Ohio Health
Columbus,
OH
Rakhi P.Naik
,MD
Johns Hopkins Hospital
Baltimore,
MD
Hematology-Focused Fellowship Training Program (HFFTP)
Dzٱ
Dana-Farber Cancer Institute, Inc.
Boston,
MA
Hematology-Focused Fellowship Training Program (HFFTP)
PallawiTorka
,MD
Roswell Park Comprehensive Cancer Center
Buffalo,
NY
International Graduate Hematology
ShrutiChaturvedi
,MBBS
Johns Hopkins University School of Medicine
Baltimore,
MD
International Graduate Hematology
ղԲⲹ¾
University of Nebraska
Omaha,
NE
Geriatric Hematology
Alexander ABoucher
,MD
University of Minnesota
Minneapolis,
MN
Lifespan Hematology
Matthew J.Maurer
,DSc
Mayo University
Rochester,
MN
Medical Informatics and AI
ܱԲ
University of Ulm
Berlin,
Germany
Medical Informatics & AI
PaulaJames
,MD, FRCPC
Queen's University
Kingston,
ON,Canada
Maternal Health
AliBazarbachi
,MD, PhD
American University of Beirut Medical Center
Beirut,
Lebanon
International Opportunities Hematology
KoheiHosokawa
,MD, PhD
Kanazawa University
Kanazawa,
Japan
International Opportunities Hematology
վܰپ
University Health Network
Toronto,
ON,Canada
Systems Based Hematology
ShannonElf
,PhD
The University of Chicago
Chicago,
IL
PhD Careers
ParvathiRanganathan
,PHD
Ohio State University
Columbus,
OH
PhD Careers
SaraVesely
,PhD
The Univ. of OK Health Sciences Ctr.
Oklahoma City,
OK
Pediatric Clinical Hematology
Angela CWeyand
,MD
University of Michigan Medical School
Ann Arbor,
MI
Pediatric Clinical Hematology
AndrewVolk
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Laboratory and Translational Hematology
SanjayMohan
,MD
Vanderbilt University Medical Center
Nashville,
TN
Medical Educators in Hematology
Tapan M.Kadia
,MD
MD Anderson Cancer Center
Houston,
TX
Medical Educators in Hematology
ٲԾմǷɲԲ
Astra Zeneca
Potomac,
MD
Industry Careers
E. Leila JeromeClay
,MD
Johns Hopkins
Watertown,
MA
Industry Careers
Julie A.Panepinto
,MD, MSPH
Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute
Bethesda,
MD
Government Careers (NIH and FDA)
CaraRabik
,MD,PhD
Food and Drug Administration
Silver Spring,
MD
Government Careers (NIH and FDA)
Adrienne MHammill
,MD, PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
ܱ
Columbus Oncology and Hematology
Columbus,
OH
Private Practice Hematology
MariaCarter Febres
,MD
Cincinnati Children's Hospital
Cincinnati,
OH
Pediatric Hematology
Alfred ILee
,MD, PhD
Yale University School of Medicine
New Haven,
CT
Adult Classical Hematology
PayalDesai
,MD
Wake Forest University
Charlotte,
NC
Adult Classical Hematology
HannyAl-Samkari
,MD
Massachusetts General Hospital, Harvard Medical School
Boston,
MA
Adult Classical Hematology
SumithiraVasu
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult Malignant Hematology
BasemWilliam
,MD
OhioHealth Marion General Hospital
Columbus,
OH
Adult Malignant Hematology
²
Ohio State University Medical Center
Columbus,
OH
Adult Malignant Hematology
Nirali N.Shah
,MD
NIH
Bethesda,
MD
Pediatric BMT/CAR-T
RayneRouce
,MD
Texas Children's Hospital
Houston,
TX
Pediatric BMT/CAR-T
Abdullah MohammadKhan
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult BMT/Cellular Therapy
NareshBumma
,MD
The Ohio State University Comprehensive Cancer Center
COLUMBUS,
OH
Adult BMT/Cellular Therapy
Monique A.Hartley-Brown
,MD
DFCI
Boston,
MA
Adult BMT/Cellular Therapy
Ჹ
MD Anderson Medical Center
Loma Linda,
TX
Pediatric BMT/CAR-T
Mikkael A.Sekeres
,MD
University of Miami Miller School of Medicine
Miami,
FL
Adult Malignant Hematology
OyebimpeAdesina
,MD,MS
UC Davis Comprehensive Cancer Center
Sacramento,
CA
Adult Classical Hematology
YiZheng
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
StevenFein
,MD,MPH
University of Miami
Miami,
FL
Private Practice Hematology
Elaine S.Jaffe
,MD
National Cancer Institute, National Institute of Health
Bethesda,
MD
Government Careers (NIH and FDA)
Ѳܻ
Bristol Myers Squibb
Madison,
NJ
Industry Careers
Alisa SWolberg
,PhD
University of North Carolina at Chapel Hill
Chapel Hill,
NC
Laboratory and Translational Hematology
ԻⲹʲԳ
National Institutes of Health
Seattle,
WA
Medical Educators in Hematology
Sarah H.O'Brien
,MD,MSc
Ohio State University
Columbus,
OH
Pediatric Clinical Hematology
MargaretGoodell
,PhD
Center for Cell and Gene Therapy, Baylor College of Medicine
Houston,
TX
PhD Careers
ǰʲ
University of California
Oakland,
CA
Systems Based Hematology
dz
Baskent University
Ankara,
Turkey
International Opportunities Hematology
LisaBaumann Kreuziger
,MD, MS
Versiti
Milwaukee,
WI
Maternal Health
James S.Blachly
,MD
The Ohio State University
Columbus,
OH
Medical Informatics & AI
RebeccaKruse-Jarres
,MD,MPH
University of Washington
Seattle,
WA
Lifespan Hematology
AshleyRosko
,MD
The Ohio State University
Columbus,
OH
Geriatric Hematology
첹Գٳ
Baptist Health South Florida
Miami,
FL
International Graduate Hematology
Myeloid Malignancies
ѻý Program
A Little Less Conversation, a Little More Action: An Outcome Equity Roadmap for Children and AYAs With Leukemia and Lymphoma
Centuries of structural racism have contributed to discrimination, environmental and social injustice, and household material hardship among historically marginalized populations. Recent studies have highlighted the impact of factors such as income and insurance status on cancer outcomes and health equity. Under-representation of specific groups has limited our understanding of cancer risk, disease biology, treatment-related toxicities, and patient-reported outcomes. The educational objective of this session is to present the latest evidence regarding modifiable factors that contribute to outcome disparities in childhood/adolescent and young adult (AYA) hematologic malignancies, and to discuss potential targets for interventions that address these disparities. Dr. Ji will present an in-depth overview of public health insurance programs in the U.S. and related implications on outcome disparities among AYAs with blood cancers. Using a case-based approach, Dr. Ji will discuss opportunities to improve access to high-quality public health insurance, subsequent to the Affordable Care Act. Dr. Umaretiya will discuss the role of social determinants of health (SDOH) as modifiable drivers of outcome inequities in pediatric oncology. She will review the prevalence of SDOH in pediatric oncology, present historically marginalized parent perspectives on unmet social needs during cancer care, and highlight novel interventions addressing this population’s SDOH and social needs. Dr. Mittal will discuss factors contributing to low rates of enrollment of AYAs with hematologic malignancies to clinical trials, including a lack of availability and accessibility. She will provide an up-to-date review of collaborative initiatives that are addressing some of these barriers to improve AYA access to cancer clinical trials.
Chair:
Maria Monica MonicaGramatges,MD,PhD
Texas Children's Hospital
Houston,
TX
Speakers:
XuJi,PhD
Emory University School of Medicine
Atlanta,
GA
The Lasting Impact of the ACA: How Medicaid Expansion Reduces Outcome Disparities in AYAs With Leukemia and Lymphoma
Puja J.Umaretiya,MD
Childrens Medical Center Dallas, UT Southwestern
Dallas,
TX
Targeting Hardship: Poverty as a Modifiable Risk Factor in Childhood Leukemia and Lymphoma Treatment
Nupur MittalNupur Mittal
Rush University Medical Center
Chicago,
IL
Sharing is Caring: A Network Collaborative Approach to Identify and Address Barriers in Accessing Clinical Trials in AYAs with Leukemia and Lymphoma
AML M&Ms: How to Integrate Mutations and MRD Data
The genomic heterogeneity of AML, the clinical variability of patients and patient outcomes to various therapies, and the underlying awareness and evaluation of clonal evolution mandates an integrated approach to AML risk assessment and treatment decision-making. This session will focus on the clinical management of AML using a comprehensive evaluation including both genetic characterization and MRD-based response assessments during therapy, to optimize the clinical outcomes of patients with AML.
Dr. Jerald Radich will examine the role of MRD as an indicator of treatment response, and help answer the question of why some patients with persistent MRD do not relapse, while others without detectable MRD may still relapse nonetheless. He will explore how to best use MRD to optimize patient care, and explore how the mutational landscape of AML at diagnosis and during therapy can help to explain not only the clinical utility of MRD but also key features of leukemia biology.
Dr. Michael Heuser will discuss the prognostic impact of MRD status in different genetic risk groups and provide an overview on the available MRD technologies to monitor treatment response in transplant-eligible patients with AML. He will help to unravel the complex matrix of MRD and mutational dependencies for practical clinical application and management decisions in patients with AML.
Dr. Courtney DiNardo will summarize the current treatment landscape of AML in patients ineligible for transplant, and focus on the importance of a comprehensive genomic assessment to identify optimal treatment strategies both at diagnosis and relapse. She will also highlight the role of MRD assessments and review the role of MRD measurements to guide treatment decisions in patients receiving non-intensive therapies.
Chair:
Courtney D.DiNardo,MD,MSc
MD Anderson Cancer Center
Houston,
TX
Speakers:
Jerald P.Radich,MD
University of Washington School of Medicine
Seattle,
WA
Mutations and MRD: Clinical Implications of Clonal Ontogeny
MichaelHeuser,MD
Hannover Medical School
Hannover,
Germany
Mutation and MRD-informed Treatment Decisions for the Transplant-Eligible Patient
Courtney D.DiNardo,MD,MSc
MD Anderson Cancer Center
Houston,
TX
Incorporating Mutational Data and MRD Assessments into Treatment Decisions for Transplant-Ineligible Patients
Chasing Zebras: Navigating Rare Myeloid Neoplasms
It turns out the old adage from our medical school days, “If you hear hoofbeats, think of horses, not zebras,” was not completely correct! Indeed, the diagnosis of a “rare disease” turns out to be not as rare as we previously thought. The faculty speaking in this important session have focused their entire careers to patient care and cutting-edge research in areas of rare and even ultra-rare hematologic malignancies. The coupling of increasing pathologic technology and diagnostic methods along with augmented education and awareness have shed light on some of the more rare blood cancers in our field, especially over the past decade. In particular, in the field of myeloid neoplasms, the emerging importance of dividing these entities into specific subgroups distinguished by unique clinicopathologic characteristics has had a tremendous impact not only on diagnosis, but also on prognosis and development of novel treatment decision approaches.
In this first talk, Dr Robert P Hasserjian focuses his remarks on understanding the growing field of chronic neutrophilic leukemia (CNL) and CSF3R-related disorders. In the decade since the elucidation by, Maxson et al (Maxson, NEJM 2013), of frequent oncogenic CSF3R mutations in patients with CNL and atypical CML, this field has rapidly expanded as we are beginning to understand that these Philadelphia negative hematologic myeloid malignancies are more commonly present than we previously thought.
In the second talk, Dr Naveen Pemmaraju highlights the encouraging developments in a rapidly emerging field in hematologic malignancies, that of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN). BPDCN is a singularly unique malignancy that is known for involving cutaneous sites, followed by bone marrow/blood lymph nodes, and of interest, a high rate of CNS involvement. Despite many nomenclature and disease category changes over the past three decades, BPDCN is now recognized as its own unique entity which expresses, via flow cytometry and immunohistochemistry: CD123+, along with CD4+, CD56+, TCL-1+ and TCF-4+. The clinical pioneering of the first approved CD123-targeted agent in the field (tagraxofusp, led by Pemmaraju et al NEJM April 2019) has led to the development of a worldwide clinical/translational interest in BPDCN, targeting CD123 by various therapeutic approaches, and for interest in developing combination approaches and CNS-directed therapies for this rare blood cancer.
In the final talk of this session, Dr Olga Weinberg very nicely draws attention to acute leukemias of ambiguous lineage, a field that is rapidly growing as it benefits from deeper, faster, and more directed targeted sequencing efforts and improved patho-biologic understanding of the various subsets that make up this unique entity. Among the keys to this topic will be understanding several of the newer tests, at the level of the blood, bone marrow, flow cytometry, cytogenetics and molecular next generation sequencing that are available in the pathologists’ and clinicians’ tool kits in searching for identification and diagnosis of particular subtypes of this historically elusive diagnosis that is becoming more and more common to encounter.
Chair:
NaveenPemmaraju,MD
MD Anderson Cancer Center
Houston,
TX
Speakers:
Robert PHasserjian,MD
Massachusetts General Hospital
Boston,
MA
The Spectrum of Ph Negative Disease: CNL and CSF3R-Related Disorders
NaveenPemmaraju,MD
MD Anderson Cancer Center
Houston,
TX
BPDCN State of the Art
Olga K.Weinberg,MD
UT Southwestern
Dallas,
TX
How to Think About Acute Leukemia of Ambiguous Lineage
Handling Bad News: How to Best Manage TP53 Myeloid Disease?
Mutations of TP53 are present in 10-15% of cases of de novo acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) and approximately 30% of cases of therapy-related myeloid neoplasms. TP53-mutated myeloid disease is associated with complex cytogenetic abnormalities and poor outcome, with a median survival of only 5-10 months. In this educational session, we will explore the impact of TP53 mutation type and number on outcomes and clinical management. We will review current and emerging treatment approaches for this high-risk subtype of AML/MDS.
Dr. Daniel Link will discuss evidence that TP53 hotspot mutations have dominant negative or gain-of function properties and discuss the potential impact on outcome and clinical management. He will review recent data establishing the importance of determining TP53 mutant allele status (monoallelic versus multi-hit).
Dr. Marina Konopleva will review current non-transplant therapeutic approaches for TP53-mutated myeloid disease and discuss new therapies on the horizon, including chimeric antigen receptor therapies, mutated p53 reactivators, Fc fusion protein and monoclonal antibodies targeting various myeloid antigens.
Dr. Hugo Fernandez will discuss the use of allogenic hematopoietic transplant in the treatment of TP53-mutated myeloid disease, including new approaches to tailor conditioning and use maintenance therapy after transplantation.
Chair:
Daniel CLink,MD
Washington University School of Medicine in St. Louis
Saint Louis,
MO
Speakers:
Daniel CLink,MD
Washington University School of Medicine in St. Louis
Saint Louis,
MO
Are TP53 Mutations All Alike?
MarinaKonopleva
Albert Einstein College of Medicine
Houston,
TX
Non-transplant Treatment Approaches for High-risk TP53 Myeloid Disease
Hugo FranciscoFernandez,MD
Moffitt Malignant Hematology and Cellular Therapy
Pembroke Pines,
FL
Transplant Options and Outcomes for TP53 Myeloid Disease
Ironing Out the Wrinkles: Managing Iron Overload in Different Clinical Scenarios
Iron homeostasis and porphyrin metabolism must be closely coordinated to ensure efficient biosynthesis of heme. Disturbed coordination is exemplified by sideroblastic anemias, which are characterized by insufficient incorporation of iron into the end product of the prophyrin biosynthesis pathway, resulting in anemia and mitochondrial as well as systemic iron overload. Conversely, iron overload from other causes, like hereditary hemochromatosis, can have unfavourable effects on porphyrin synthesis, provoking porphyria cutanea tarda. The intricate interplay between iron and porphyrin metabolism can be disturbed by inherited or acquired causes. Therapeutic options to mitigate the ensuing clinical symptoms are highlighted by the three speakers of this session.
Dr. Domenico Girelli will discuss hereditary hemochromatosis according to the recent clinically oriented classification. While hyperferritinemia is common in practice, hemochromatosis accounts for few cases, typically with increased transferrin saturation. HFE-related hemochromatosis has a low penetrance, influenced by lifestyle and dysmetabolic factors. Most patients are currently identified in the early phases before life-threatening manifestations. Phlebotomy remains the mainstay for achieving iron depletion, with blood donation being an option for maintenance. The management of rare, severe non-HFE forms, requiring a comprehensive approach, will also be presented.
Dr. Norbert Gattermann will outline the pathophysiology of systemic iron overload in MDS as well as mitochondrial iron accumulation in patients with acquired sideroblastic anemias. He will explain how SF3B1 mutations and the subsequent missplicing and deficiency of ABCB7 may lead to impaired heme synthesis and excess mitochondrial iron. The rationale for iron chelation therapy in MDS will be considered, together with some of its practical aspects. Finally, Dr. Gattermann will assess the extent to which luspatercept might contribute to the management of iron overload in patients with MDS.
Dr. Rebecca Leaf will focus on porphyria cutanea tarda (PCT), a disorder of heme biosynthesis that arises due to inhibition of hepatic uroporphyrinogen decarboxylase in the setting of increased liver iron content and oxidative stress. Patients with PCT invariably have siderosis on liver biopsy and up to 20% are homozygous for the HFE C282Y mutation. PCT manifests as blistering cutaneous lesions on sun-exposed areas, skin fragility, and elevated plasma and urine porphyrins. Treatment includes therapeutic phlebotomy to decrease total body iron levels and hydroxychloroquine, which reduces hepatic porphyrin content.
Chair:
NorbertGattermann,MD
Heinrich Heine University Dusseldorf
Dusseldorf,
Germany
Speakers:
DomenicoGirelli,MD,PhD
University of Verona
Verona,
Italy
Diagnosis and Management of Hereditary Hemochromatosis: Lifestyle Modification, Phlebotomy, and Blood Donation
NorbertGattermann,MD
Heinrich Heine University Dusseldorf
Dusseldorf,
Germany
Management of Iron Overload in Acquired Sideroblastic Anemias and MDS: Role of Chelation and Luspatercept
RebeccaLeaf
Mass General Hospital Cancer Center
Boston,
MA
Porphyria Cutanea Tarda: A Unique Iron-Related Disorder
MPN Practice Pearls: Profiling, Pegylated IFN and Pregnancy
This MPN session focuses on issues of clinical relevance while emphasizing disease biology. The clinical care of patients with MPN is evolving, with increasing evidence indicating that molecular genetic data is an important component of care, both at diagnosis and during follow up. Approximately three years after the approval of ropeginterferon by the Food and Drug Administration (FDA) for the treatment of Polycythemia Vera (PV), it is timely to review the role of pegylated interferon in the treatment of MPN. Finally, as the obstetric population with MPN increases, understanding how to optimize care for patients with MPN during pregnancy is increasingly relevant. Attendees can expect to learn MPN practice pearls in all three sessions!
Dr. Mead will discuss current approaches to molecular profiling of MPN patients, using illustrative clinical case histories to demonstrate how genetic analysis is already fully integrated into MPN diagnostic classification and prognostic risk stratification. He will discuss how molecular profiling can also be used in MPN to measure response to therapy both in clinical trials and routine clinical practice. Taking a forward look, he will discuss how molecular profiling in MPN might be used in the future to select specific molecularly targeted therapies and the role of additional genetic methodologies beyond mutation analysis.
Dr. Kiladjian will discuss the use of pegylated interferon for the treatment of MPN and review the different types of pegylated interferon currently available. He will review in which MPN subtypes pegylated interferon has the greatest clinical efficacy and discuss both hematological and molecular response. He will review the mechanism of action of pegylated interferon and link this to potential for disease modification and prevention of MPN progression. Finally, he will review the limitations of clinical studies with respect to their ability to measure MPN progression, as well as the need for more comprehensive assessment of molecular response.
Dr. Chi-Joan How will discuss practices around the management of pregnancy in MPN patients. As the obstetric population ages and MPNs are being increasingly diagnosed in younger patients, pregnancy in MPNs will become more frequently encountered. She will discuss current data surrounding pregnancy outcomes in MPNs and current recommendations for the use of anti-platelet agents, anticoagulation, and cytoreduction in the ante- and post-partum period. Using a case-based approach, Dr. How will suggest best practices in areas with limited data.
Chair:
AnnMullally,MD
Stanford University School of Medicine
Stanford,
CA
Speakers:
Adam JMead,PhD, MRCP, FRCPath
University of Oxford
Oxford,
ENG,United Kingdom
Molecular Profiling in MPN: Who Should Have It and Why?
Jean-JacquesKiladjian,MD, PhD
Hopital Saint-Louis
Paris,
France
Pegylated IFN: The Who, Why, and How
Chi-JoanHow,MD
Brigham and Women's Hospital
Boston,
MA
Pregnancy: MPN Management Before, During, and After Pregnancy
ѻý Spotlight Sessions
The Clone Wars: Myeloid Neoplasia Risk in Clonal Hematopoiesis
Clonal expansions in the hematopoietic system, referred to as clonal hematopoiesis (CH), is common throughout life and associated with significant clinical outcomes, including increased risk of hematologic cancers, all-cause mortality and nonmalignant conditions. Recently, clinical definitions of disorders within the spectrum of CH have been introduced, including clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS), providing the framework for harmonized classification and registration. However, while clone features and dynamics have been well described, relevant key issues remain to be clarified.
In the first presentation, Dr. Malcovati will provide an overview of biological underpinnings and clinical implications of CH. In addition, the spectrum of clonal cytopenias, as well as current classification framework and its pitfalls, will be critically discussed. Finally, the contribution of intra- and extra-clonal factors to clonal evolution, and the models developed for predicting the risk of developing myeloid neoplasms and the trajectory of evolution will be reviewed, as a basis for informing early-detection and prevention strategies.
In the second presentation, Dr Grønbæk will discuss the clinical management of CH in everyday clinical practice, focusing on how individual/patients with CH are identified, including the incidental finding, which emphasizes the need for informed consent before sequencing. She will elaborate on the importance of identifying and following high-risk individuals/patients while sparing low risk individuals unnecessary worries. The importance of enrolling these individuals/patients in clinical trials will be discussed including the optimal trials designs. Examples of ongoing trials will be presented and critically appraised.
Chair:
LucaMalcovati,MD
University of Pavia and S. Matteo Hospital
Pavia,
Italy
Speakers:
LucaMalcovati,MD
University of Pavia
Pavia,
Italy
Predicting Risk of MN in CH
KirstenGronbaek,Professor, MD, DMSc
Kirsten Grønbæk
Copenhagen N,
Denmark
How to Follow CH Patients
Marquee Sessions
2024 Presidential Symposium
Red cells constitute ~70% of all cells in the human body and in healthy individuals their circulatory life span is ~ 120 days. At steady state the bone marrow produces 2.5 million red cells per second to maintain normal hemoglobin levels. Anemia characterized by decreased hemoglobin levels is a major global health problem affecting nearly 2 billion individuals. Decreased red cell life span and/or decreased red cell production in the bone marrow account for anemia in various inherited and acquired hemolytic anemias. Significant progress has been and is continuing to be made in our understanding of the mechanistic basis for anemia. The three presentations in the symposium will highlight recent advances in our understanding of red cell biology and of anemia.
Dr. Patrick Gallagher will discuss recent advances which have expanded understanding of the many roles of the erythrocyte membrane. An update on the diagnosis and treatment of membrane disorders and potential emerging therapies will be discussed.
Dr. Naomi Taylor will highlight the pivotal role of metabolite transporters and fuel choice in erythroid lineage commitment and terminal erythroid differentiation. The importance of metabolic reprogramming in diseases of disordered and ineffective erythropoiesis will be discussed.
Dr. Olivier Hermine will explain the mechanisms that control red cell production during terminal erythroid differentiation, focusing on the processes that determine the fate of erythroid precursors between differentiation or cell death. The discussion will also touch upon how these mechanisms are impacted in hemoglobinopathies and myelodysplastic disorders, which can result in ineffective erythropoiesis and anemia. Additionally, therapeutic implications arising from these insights will be emphasized.
Chair:
MohandasNarla,DSc
New York Blood Center
New York,
NY
Speakers:
Patrick GGallagher,MD
Abigail Wexner Research Institute at Nationwide Children's Hospital
Columbus,
OH
Mature Red Cell Membrane Disorders (including genome-wide screening and PK activators)
NaomiTaylor,MD
National Institutes of Health
Bethesda,
MD
Metabolism and Erythropoiesis (including metabolism, IDH mutations and relevance to MDS, sideroblastic anemia)
OlivierHermine,MD,PhD
IMAGINE institute Paris France
Paris,
France
Ineffective Erythropoiesis in Thalassemia and Sickle Cell Disease
ASH-EHA Joint Symposium
Session Overview
The ASH-EHA Joint Symposium is intended to address global issues in hematology from both the North American and European perspectives and provide insight on how international collaboration can help confront these issues. The first of these sessions was held at the ASH Annual Meeting in December 2005, and has taken place twice each year since at the European Hematology Association’s (EHA) Annual Congress in June and the ASH Annual Meeting in December. The leadership of both societies determine the recommended topics and speakers for these events each year, with the society presidents co-chairing the event. This year's topic is Myelodysplasia.
Myelodysplasia
Myelodysplasia and Myeloproliferative syndromes are complex and heterogeneous clinical entities with varying progression rates. Significant progress is being made in our understanding of the molecular and genetic basis for these disorders. These insights are being used to develop new strategies for optimal patient-specific treatment modalities for effective and optimal clinical management of these disorders. Dr. Amy DeZern will discuss prognostication and risk stratification strategies for patients with myelodysplastic syndromes. Dr. Matteo Della Porta will discuss the targeting of cytopenias in low-risk MDS.
CoChair:
Speakers:
Amy E.DeZern,MD
Johns Hopkins University
Baltimore,
MD
Prognostication and risk stratification strategies for patients with myelodysplastic syndromes
Matteo GiovanniDella Porta,MD
IRCCS Humanitas Research Hospital
Rozzano,
Milan,Italy
Targeting of Cytopenias in Low-Risk MDS
Scientific Program
Ineffective Erythropoiesis: Insights Into Molecular Mechanisms and Disease Pathophysiology
Scientific Committee on Red Cell Biology
Ineffective erythropoiesis is the leading cause of red cell-related diseases, including anemia, which stands as the most prevalent hematologic disease, affecting millions of individuals worldwide. Understanding the underlying mechanisms of ineffective erythropoiesis is pivotal for advancing diagnostic and therapeutic approaches in hereditary anemias and adult-onset conditions. This session will explore recent breakthroughs in research related to ineffective erythropoiesis, focusing on areas of hemoglobinopathies, malaria infection, and myeloid neoplasms. By bringing together experts at the forefront of these investigations, the session will not only enhance understanding of the pathogenesis of ineffective erythropoiesis but also catalyze the development of innovative approaches to treat related diseases.
Chair:
PengJi,MD,PhD
Northwestern University Medical School
Chicago,
IL
Speakers:
WassimEl Nemer,PhD
French Blood Establishment (EFS)
Marseille,
France
Post-Transcriptional and Signaling Mechanisms in Ineffective Erythropoiesis in Hemoglobinopathies
Elizabeth S.Egan,MD, PhD
Stanford University School of Medicine
Stanford,
CA
Plasmodium Falciparum Influences Erythropoiesis
SergeiDoulatov,PhD
Division of Hematology, Department of Medicine
Seattle,
WA
Ineffective Erythropoiesis in Myeloid Neoplasms
Metabolic Deregulation in Hematopoietic Neoplasia: Tumor, The Environment, and Therapies.
Scientific Committee on Hematopathology and Clinical Laboratory Hematology
Cellular metabolism and its role in the pathogenesis of hematologic malignancies is an emerging area of research. Recent studies implicate various cellular mechanisms by which oncogenic activation of metabolic pathways contribute to lymphoid and myeloid malignancies as well as their respective tumor environment. In this session, the speakers will discuss the role of deregulated cellular metabolism that contributes to lymphoid and myeloid malignancies and how they may provide novel insights with therapeutic relevance. The metabolic control of T cell differentiation and their function in immunity will also be discussed. This session highlights the opportunities for gaining novel mechanistic insights of hematologic malignancies through global metabolomic studies that has potential to impact the field of T-cell immunology, immunotherapies and facilitate translation to clinical practice.
Chair:
Megan S. SLim,MD,PhD
Memorial Sloan Kettering Cancer Center
New York City,
NY
Speakers:
Jürgen MaximilianRuland
Technical University of Munich
Munich,
Germany
Novel Insights in Metabolic Deregulation in Lymphoid Malignancies
PaoloGallipoli,MD
Queen Mary University of London
London,
United Kingdom
Targeting Metabolic Deregulation in Acute Myeloid Leukemia
AnandaGoldrath,PhD
Allen Institute
Seattle,
WA
Metabolic Control of T Cell Differentiation and Function in Tumor Immunity
Special-Interest Sessions
ASH Clinical Practice Guidelines on Amyloidosis
This session will review the scope and goals of the upcoming guidelines on amyloidosis, and will provide insights on risk factors, selecting a target site versus a surrogate site for diagnostic biopsies, and using Congo Red stain screening.
Chair:
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University Health Network
Toronto,
ON,Canada
Speakers:
AngelaDispenzieri,MD
Mayo Clinic
Rochester,
MN
Target Site vs. Surrogate Site Biopsy for Diagnosis
JoselleCook,MBBS
Mayo
Rochester,
MN
Increasing Awareness of Risk Factors for AL Amyloidosis
NareshBumma,MD
The Ohio State University
Columbus,
OH
Congo Red Stain Screening for AL Amyloidosis
HiraShaikh,MD
University of Iowa Caver College of Medicine
Coralville,
IA
Target Site Vs. Surrogate Site Biopsy for Diagnosis
Race and Ancestry in Precision Medicine
Race and ancestry, historically, have been poorly considered in basic and translational research design and clinical diagnoses. This session will describe how race and ancestry can inform hematology research conduct, specifically in clinical and genetic population profiling, interpretation of common hematologic tests, development of diagnostics, and overall precision medicine. The speakers selected in this session have incorporated race and ancestry in their own research and will be sharing their insights to help educate hematology investigators and clinicians understand how to consider race and ancestry into their own research and practice.
CoChair:
Speakers:
KeoluFox
University of California, San Diego
San Diego,
CA
Incorporating Indigenous Perspectives into Population Genetics
Ann-KathrinEisfeld,MD
The Ohio State University Comprehensive Cancer Center
Columbus,
OH
Risk Re-Stratification Based on Black AML Patient Exome Data
MaureenAchebe
Brigham and Women's Hospital
Boston,
MA
How Inappropriate Reference Ranges Can Propagate Systemic Racism
Symposium on Quality: Treating Fairly - The Role of Quality Improvement in Combating Health Care Disparities
This year's Quality Symposium will focus on practical strategies for combatting healthcare disparities. First, Dr. Melissa Creary will discuss the Michigan Social Health Interventions to Eliminate Disparities (MSHIELD) program, a statewide data-driven, community-partnered, and equity-centered quality improvement effort. Then Dr. Michelle Sholzberg will review the development and impact of the "Raise the Bar" project, which aims to eliminate disparities in the recognition and management of iron deficiency by adjusting reference ranges. The session will conclude with a talk by Dr. Thomas Greg Knight on mitigating the impact of financial toxicity in patients with hematologic malignancies.
CoChair:
Speakers:
MelissaCreary
University of Michigan School of Public Health
Ann Arbor,
MI
MSHIELD - Michigan Social Health Interventions to Eliminate Disparities
MichelleSholzberg,MDCM, MSc
University of Toronto
Toronto,
ON,Canada
Raise the Bar - Combatting Disparities in the Recognition and Management of Iron Deficiency
Thomas G.Knight,MD
Atrium Health
Charlotte,
NC
Cancer and Poverty - Mitigating the Impact of Financial Toxicity in Patients with Hematologic Malignancies
Trainee Activities and Services
Blood Buddies: Adult Clinical Malignant Hematology
Trainees have the opportunity to meet with leaders in the field. Trainees sign up for a one-on-one Blood Buddy ten-minute mentoring session with a faculty member. Blood Buddies are experts in various hematology topic areas. This is an excellent opportunity for trainees to network with and receive mentorship from seasoned faculty. There are 3 Blood Buddies sessions at the event. Although the speakers roles are marked as primary and alternate, multiple speakers may be asked to present on the same topic if that topic will be repeated in the following sets of Blood Buddies. The featured topics are: Adult Clinical Malignant Hematology; Pediatric Clinical Malignant Hematology; Adult Clinical Classical Hematology; Pediatric Clinical Classical Hematology; BMT Pediatric and Adult; Quality Improvement; Medical ѻý; PhD/Laboratory; Diversity, Equity, and Inclusion; International Medical Graduates; Future of Hematology (Artificial Intelligence); Industry Career Pathway; Federal Career Pathway.
Career Development Lunch
This session provides an intimate venue for trainees to meet with leaders in hematology to discuss careers in the wide array of practice areas within hematology, including basic, clinical, and translational research, PhD careers, careers in industry settings, and careers in private and clinical practice. There will are multiple tables dedicated to each career area and one faculty member at each table leading the discussion. A boxed lunch is provided. This is a first come, first served event that is usually very-well attended. The full list of topics covered are: Adult BMT; Pediatric BMT; Adult Clinical Malignant Hematology; Adult Clinical Classical Hematology; Clinical Careers in Hematology (Private Practice Careers); Government Careers (NIH and FDA); Industry Careers; Laboratory and Translational Hematology; Medical Educators in Hematology; Pediatric Clinical Hematology; PhD careers; Systems-Based Hematology; Global Hematology; Maternal Health; Medical Informatics and AI; Lifespan; and Geriatric Hematology.
Chair:
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Moffitt Cancer Center
Lutz,
FL
Yvonne A.Efebera,MD
Ohio Health
Columbus,
OH
Rakhi P.Naik
,MD
Johns Hopkins Hospital
Baltimore,
MD
Hematology-Focused Fellowship Training Program (HFFTP)
Dzٱ
Dana-Farber Cancer Institute, Inc.
Boston,
MA
Hematology-Focused Fellowship Training Program (HFFTP)
PallawiTorka
,MD
Roswell Park Comprehensive Cancer Center
Buffalo,
NY
International Graduate Hematology
ShrutiChaturvedi
,MBBS
Johns Hopkins University School of Medicine
Baltimore,
MD
International Graduate Hematology
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University of Nebraska
Omaha,
NE
Geriatric Hematology
Alexander ABoucher
,MD
University of Minnesota
Minneapolis,
MN
Lifespan Hematology
Matthew J.Maurer
,DSc
Mayo University
Rochester,
MN
Medical Informatics and AI
ܱԲ
University of Ulm
Berlin,
Germany
Medical Informatics & AI
PaulaJames
,MD, FRCPC
Queen's University
Kingston,
ON,Canada
Maternal Health
AliBazarbachi
,MD, PhD
American University of Beirut Medical Center
Beirut,
Lebanon
International Opportunities Hematology
KoheiHosokawa
,MD, PhD
Kanazawa University
Kanazawa,
Japan
International Opportunities Hematology
վܰپ
University Health Network
Toronto,
ON,Canada
Systems Based Hematology
ShannonElf
,PhD
The University of Chicago
Chicago,
IL
PhD Careers
ParvathiRanganathan
,PHD
Ohio State University
Columbus,
OH
PhD Careers
SaraVesely
,PhD
The Univ. of OK Health Sciences Ctr.
Oklahoma City,
OK
Pediatric Clinical Hematology
Angela CWeyand
,MD
University of Michigan Medical School
Ann Arbor,
MI
Pediatric Clinical Hematology
AndrewVolk
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Laboratory and Translational Hematology
SanjayMohan
,MD
Vanderbilt University Medical Center
Nashville,
TN
Medical Educators in Hematology
Tapan M.Kadia
,MD
MD Anderson Cancer Center
Houston,
TX
Medical Educators in Hematology
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Astra Zeneca
Potomac,
MD
Industry Careers
E. Leila JeromeClay
,MD
Johns Hopkins
Watertown,
MA
Industry Careers
Julie A.Panepinto
,MD, MSPH
Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute
Bethesda,
MD
Government Careers (NIH and FDA)
CaraRabik
,MD,PhD
Food and Drug Administration
Silver Spring,
MD
Government Careers (NIH and FDA)
Adrienne MHammill
,MD, PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
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Columbus Oncology and Hematology
Columbus,
OH
Private Practice Hematology
MariaCarter Febres
,MD
Cincinnati Children's Hospital
Cincinnati,
OH
Pediatric Hematology
Alfred ILee
,MD, PhD
Yale University School of Medicine
New Haven,
CT
Adult Classical Hematology
PayalDesai
,MD
Wake Forest University
Charlotte,
NC
Adult Classical Hematology
HannyAl-Samkari
,MD
Massachusetts General Hospital, Harvard Medical School
Boston,
MA
Adult Classical Hematology
SumithiraVasu
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult Malignant Hematology
BasemWilliam
,MD
OhioHealth Marion General Hospital
Columbus,
OH
Adult Malignant Hematology
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Ohio State University Medical Center
Columbus,
OH
Adult Malignant Hematology
Nirali N.Shah
,MD
NIH
Bethesda,
MD
Pediatric BMT/CAR-T
RayneRouce
,MD
Texas Children's Hospital
Houston,
TX
Pediatric BMT/CAR-T
Abdullah MohammadKhan
,MD, MBBS
The Ohio State University
Columbus,
OH
Adult BMT/Cellular Therapy
NareshBumma
,MD
The Ohio State University Comprehensive Cancer Center
COLUMBUS,
OH
Adult BMT/Cellular Therapy
Monique A.Hartley-Brown
,MD
DFCI
Boston,
MA
Adult BMT/Cellular Therapy
Ჹ
MD Anderson Medical Center
Loma Linda,
TX
Pediatric BMT/CAR-T
Mikkael A.Sekeres
,MD
University of Miami Miller School of Medicine
Miami,
FL
Adult Malignant Hematology
OyebimpeAdesina
,MD,MS
UC Davis Comprehensive Cancer Center
Sacramento,
CA
Adult Classical Hematology
YiZheng
,PhD
Cincinnati Children's Hospital Medical Center
Cincinnati,
OH
Pediatric Hematology
StevenFein
,MD,MPH
University of Miami
Miami,
FL
Private Practice Hematology
Elaine S.Jaffe
,MD
National Cancer Institute, National Institute of Health
Bethesda,
MD
Government Careers (NIH and FDA)
Ѳܻ
Bristol Myers Squibb
Madison,
NJ
Industry Careers
Alisa SWolberg
,PhD
University of North Carolina at Chapel Hill
Chapel Hill,
NC
Laboratory and Translational Hematology
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National Institutes of Health
Seattle,
WA
Medical Educators in Hematology
Sarah H.O'Brien
,MD,MSc
Ohio State University
Columbus,
OH
Pediatric Clinical Hematology
MargaretGoodell
,PhD
Center for Cell and Gene Therapy, Baylor College of Medicine
Houston,
TX
PhD Careers
ǰʲ
University of California
Oakland,
CA
Systems Based Hematology
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Baskent University
Ankara,
Turkey
International Opportunities Hematology
LisaBaumann Kreuziger
,MD, MS
Versiti
Milwaukee,
WI
Maternal Health
James S.Blachly
,MD
The Ohio State University
Columbus,
OH
Medical Informatics & AI
RebeccaKruse-Jarres
,MD,MPH
University of Washington
Seattle,
WA
Lifespan Hematology
AshleyRosko
,MD
The Ohio State University
Columbus,
OH
Geriatric Hematology
첹Գٳ
Baptist Health South Florida
Miami,
FL
International Graduate Hematology
66th ASH Annual Meeting and exposition
Registration for ASH members will open on July 17, 2024, at 11:00 a.m. Eastern time.
Registration for non-members, groups, exhibitors, and media opens on August 7, 2024.
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